ID A0A0W0VFZ2_9GAMM Unreviewed; 683 AA.
AC A0A0W0VFZ2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=NAD dependent epimerase/dehydratase {ECO:0000313|EMBL:KTD19068.1};
DE EC=1.14.13.90 {ECO:0000313|EMBL:KTD19068.1};
GN ORFNames=Lisr_2116 {ECO:0000313|EMBL:KTD19068.1};
OS Legionella israelensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=454 {ECO:0000313|EMBL:KTD19068.1, ECO:0000313|Proteomes:UP000054761};
RN [1] {ECO:0000313|EMBL:KTD19068.1, ECO:0000313|Proteomes:UP000054761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bercovier 4 {ECO:0000313|EMBL:KTD19068.1,
RC ECO:0000313|Proteomes:UP000054761};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. SDR39U1 subfamily. {ECO:0000256|ARBA:ARBA00009353}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD19068.1}.
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DR EMBL; LNYH01000117; KTD19068.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0VFZ2; -.
DR STRING; 454.Lisr_2116; -.
DR PATRIC; fig|454.4.peg.2305; -.
DR OrthoDB; 9801773at2; -.
DR Proteomes; UP000054761; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013549; DUF1731.
DR InterPro; IPR025311; DUF4166.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR010099; SDR39U1.
DR NCBIfam; TIGR01777; yfcH; 1.
DR PANTHER; PTHR11092:SF0; EPIMERASE FAMILY PROTEIN SDR39U1; 1.
DR PANTHER; PTHR11092; SUGAR NUCLEOTIDE EPIMERASE RELATED; 1.
DR Pfam; PF08338; DUF1731; 1.
DR Pfam; PF13761; DUF4166; 1.
DR Pfam; PF01370; Epimerase; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:KTD19068.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054761}.
FT DOMAIN 58..117
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 215..375
FT /note="DUF4166"
FT /evidence="ECO:0000259|Pfam:PF13761"
FT DOMAIN 388..609
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 636..680
FT /note="DUF1731"
FT /evidence="ECO:0000259|Pfam:PF08338"
SQ SEQUENCE 683 AA; 77270 MW; 0AE548F9C211CC49 CRC64;
MTPLLKSQPE FTAVYGHNHA HPGEVAVDYE ELINLTYKIL RTDIAKIEGL DKFPWTSRDR
RILLMGDSAH ATAPNIAQGA GLCIEDAACL VSKLNRVDYL QGLSEYEQER KPRAKTVQNV
ADFIATAGQV KNPLLKTLRN RVLRATTLLT PMLQRRIFEY VVSYSLGGST KARFWQAPPL
FIVDDAPTSL IARVFPDFPL LDNHIKDFKT SKTGGSGFGV VTIEKPTFLS KLIGFFAGFP
KEMQKQPFYA EVFNLSQDFQ LWRRIFGYKT PLQKTYQTTH SLYCRFNRCM YLSEGFGGYL
DKVFQFIYNI KFQSDKSLMY ESQGITFFDS FKIPIPSFLS PKSVWTEKPI EKGWEFDGRV
SFPIIGTLFH YYGYFQIEQT DSVKNGRVII AGGSGMIGRE VCLEFIKKGY DVYCLSRSSN
TRLNIEGVKV RLIDEDWSDL IDKNTIILNL SGANPGAKRW TLSVKSEIAT SRFRVIDTII
HNIDRAQEKP LKYLQASAVG FYGHAGDAVL TEESKPIPGG ESGTKFRVKV CKEIESRAEK
AKCNVTHLRI GHVLSNTGGL LHYLRLSGFF YIGKFGSGNQ FVPFVHIQDV ARAIEFIAHN
RNIIDGAINI TAPKPCRNYE MLKELRLVKW GQGLPMPKSV LKLLIGQSSV VLTDSEQVQP
KRLLERGFEF NYKTIQEALH GLQ
//
