ID A0A0W0WF16_9GAMM Unreviewed; 350 AA.
AC A0A0W0WF16;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=Lisr_0693 {ECO:0000313|EMBL:KTD30598.1};
OS Legionella israelensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=454 {ECO:0000313|EMBL:KTD30598.1, ECO:0000313|Proteomes:UP000054761};
RN [1] {ECO:0000313|EMBL:KTD30598.1, ECO:0000313|Proteomes:UP000054761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bercovier 4 {ECO:0000313|EMBL:KTD30598.1,
RC ECO:0000313|Proteomes:UP000054761};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD30598.1}.
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DR EMBL; LNYH01000028; KTD30598.1; -; Genomic_DNA.
DR RefSeq; WP_058501071.1; NZ_UGOE01000001.1.
DR AlphaFoldDB; A0A0W0WF16; -.
DR STRING; 454.Lisr_0693; -.
DR PATRIC; fig|454.4.peg.743; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000054761; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000054761}.
FT DOMAIN 14..341
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 350 AA; 39134 MW; 5378AE51E9D7D3C8 CRC64;
MTEDVLFSQK GPLGLITLNR PASLNALSLP MIKLMQEQLQ HWQQEPDIKA VVLQAKPGKA
FCAGGDVRWL YEAGMANHPE QMRFFEHEYR LNHFIHHFPK PYISLMDGIT MGGGVGISLH
GSHPVASENF VFAMPETGIG FFPDIGASYL LARCPNNLGV YLGLTGHRLN AKQALGAGLV
KFVINSRQMP LLVDTLAQCD LSMNAHQQVS DCLKSSFASQ ENKTLNKEEW SLINTCFSKA
TVELILSALG EAGTKEAERI YQDLLQKAPL SLKVTLEQIH RAKDLTLAEC LKMDYVLVHH
FMRDHDFYEG IRALLIDKDK SPKWQPAELS QTSNAKVAEY FETIVPDLEL
//
