ID A0A0W0WI51_9GAMM Unreviewed; 438 AA.
AC A0A0W0WI51;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Guanylate cyclase {ECO:0000313|EMBL:KTD32007.1};
GN ORFNames=Lisr_0526 {ECO:0000313|EMBL:KTD32007.1};
OS Legionella israelensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=454 {ECO:0000313|EMBL:KTD32007.1, ECO:0000313|Proteomes:UP000054761};
RN [1] {ECO:0000313|EMBL:KTD32007.1, ECO:0000313|Proteomes:UP000054761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bercovier 4 {ECO:0000313|EMBL:KTD32007.1,
RC ECO:0000313|Proteomes:UP000054761};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD32007.1}.
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DR EMBL; LNYH01000017; KTD32007.1; -; Genomic_DNA.
DR RefSeq; WP_058500909.1; NZ_UGOE01000002.1.
DR AlphaFoldDB; A0A0W0WI51; -.
DR STRING; 454.Lisr_0526; -.
DR PATRIC; fig|454.4.peg.555; -.
DR OrthoDB; 9806704at2; -.
DR Proteomes; UP000054761; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054761};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..380
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 438 AA; 48895 MW; 8F29AAFFE25DC92D CRC64;
MAKKSNLYIF TFLGIFSSLI LVGAILSPLL LDKIRTTYLT LNMDVNQRQA EIIGKILSNL
LQEGQDKKKI IAAFQASLAR TEMDRGYLCL VNQESGVFLA HPLKKLIGYK VNQLKIDYLP
GVNGKPENWG EAIEKNKVSS GGILKTPSGH AELVDSYRIP NTNIRVFSHE NLDRLNKEIS
KLEKTVIITF ILLGFVVAFP ASYAALKVSR RYERQIEAEQ AKSEKLLLNI LPASIAQRLK
SEETNIANQF DDVSVLFVDI VGFTPLTSML SPQKLVDMLN NIFSQFDAIS LQYGLEKIKT
IGDAYMMAGG IPEPKPDHLK RSIEAGLAMM TFINEKYKGP EKIKIRMGLH TGPVTAGVIG
TYKFTYDLWG DTVNIASRLE STSQPGCIHC SEAVYKRMKE EYRFSARGKT SLKGLGEVPT
YFLIPEQVSE ETPENKKG
//
