ID A0A0W0WYS3_9GAMM Unreviewed; 2848 AA.
AC A0A0W0WYS3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Non-ribosomal peptide synthase {ECO:0000313|EMBL:KTD37465.1};
GN ORFNames=Lnau_0655 {ECO:0000313|EMBL:KTD37465.1};
OS Legionella nautarum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=45070 {ECO:0000313|EMBL:KTD37465.1, ECO:0000313|Proteomes:UP000054725};
RN [1] {ECO:0000313|EMBL:KTD37465.1, ECO:0000313|Proteomes:UP000054725}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49506 {ECO:0000313|EMBL:KTD37465.1,
RC ECO:0000313|Proteomes:UP000054725};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD37465.1}.
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DR EMBL; LNYO01000011; KTD37465.1; -; Genomic_DNA.
DR RefSeq; WP_058503725.1; NZ_LNYO01000011.1.
DR STRING; 45070.Lnau_0655; -.
DR PATRIC; fig|45070.6.peg.699; -.
DR OrthoDB; 5653772at2; -.
DR Proteomes; UP000054725; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd12116; A_NRPS_Ta1_like; 1.
DR CDD; cd05931; FAAL; 1.
DR CDD; cd19531; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR040097; FAAL/FAAC.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1674..1748
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2737..2812
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2848 AA; 320891 MW; AF05FFA01CB9BBAB CRC64;
MYNNKKTTIV EVLGQLASDK PEQLLYTFLT NQRDIQLTYR EFDTKAKQIA ALISNYTAAG
EPAILLYPAG LDFITALFGC FYAGIIAVPI YTHNFQLQKL LPRLESIMLD TNAKIILTTD
EIVRDKHRFI EMAQWLKDTK FIATDLQDYS LNSLPITSEL SPESIAFLQY SSGSTGIPKG
VMVTHQNLIA NLRVIRDAFG LEPNQNVVSW LPHYHDMGLI GNILGALFSQ TPLYLFSPAD
FIRKPLRWLE LISRTQATVS GGPNFAYELC SQSFRPELCK GLDLSAWEVA YNGAEMVRES
TLSRFEAIFA PYGFQGRSFH PCYGLAESTL MVSSSGKSHC TRELILDRKS LLKGQLKKES
AVSPSTVISL SSGQIQATQQ VEIVDPKTRT RCLPDQIGEI WVSGPSVCKG YWNRPEETNY
YFKASLSEDS GQQFLRTGDM GFLDQGWLYI TGRIKDLIII RGQNHSPEDI ENTVINSHPS
VSQSRVVAFS HDFDGEEGLV VLVTQPKHFS EQKIAIEQAI RKEISTKHDL VVKELIFIKR
ASIPLTSSGK VRRGESKNRY IEDRLNRLES AAEVLITEKG QTNSESNLAS TKPSPEQLIK
LNTDARFAII VNYLQKVLAR ELEVSLEAIN LIAPLNLIAV DSLSKVRIQH EIQELTGVQI
GPERLLSEAT LVELAREIAV AMKDKQSNGQ PLLELEPKEF PLSKGQQSLY FIQRLSPNNF
AYNISRAVRV VSPLDLSALE NAFKNLLNRH VALRTRIFEQ NGSCFQAVAE PFTADFKLVD
ARNWSDSDLS TCISSFSRQT FDLNSGSMAR LCVLQREQDY LLLFSVHHIV ADLVSLTVVV
AELAEYYHAE ITGEKAKLPA LLVSPQEYIH YEEEFLRSDK AQKMRQYWLD ELSDSALSLD
LPADHQRPPV KSYEGKTYHF SLPVELSKKI EELAVREGVT IYVVILSAYF VLLHRYTEKS
TITVGTPMAN RSDARFANMV YYLVNPVAIK GDFSHSLTFE DLISQIKDKT LAAILNQQYP
LAKLIDELQI KRDASSTPLF QAMFSYLNPM PGTDLSAFAL GQSGSCLNFH GLILEPYSIP
TYGAQFDLNV AISHNNNQLA STWEYSTDLF NQCTIHRMAQ HFQIILQEMV NDFSQPLNAF
ILPSFEEREQ MELWNATQTN YDLELPLHQL FELQVEKTPD AIAILDERDS LSYREFNTRV
NQVAHYLINL GVRPGSIVAI YMERSLEMVV ALYAVLKAGG AYLPLDSSYP KNHLNWVLND
AAPTLVLTGS ATPSLEVACP VLSLASGGED FKSLPKENPS LDIKPYDKAY IIYTSGSTGK
PKGVMIPHQG IRNRILWMQD EYQLDSSDRV LQKTPYTFDV SVWEFFWPLA TGASLYMSNP
GGHKDPYYLA ATIQQKQITT VHFVPSMLKP FLDNDKVSQC KSLRRIFCSG EALNPELARL
CISRLDASLY NLYGPTEASV DVSHWTCPRD QPINRVLIGK PIANTQLYIL DNHCLPVPIG
VPGELYIGGV GLALGYLNRS DLTTECFIQN PFSQDAEARL YKTGDLCRFE ISGDIEYLGR
IDNQVKIRGF RIELEEIESA VCSHPLVNEA VALAVHDASG SARLALYFVV KGSANPPLSE
LRNYLSDRLP EHMIPAFFKQ LDELPLLPNG KVDRKALRDL GISLPAVKSR NYIAPVTPME
ILLCKIYEEI LQVDRISISD NFFDLGGDSL LVLRAVAKLR ELEVEVTIQQ LYSNATVAEV
AALIEKNDKA DDKRSTAEQF SLINPIDLAK LPASLEDAYP LSKMQEGLVF HSEFSPDYEI
YVMGLHLRLP LSLESVHEAL AMLVKRHPLL RTSFDLIHYS EPLQLVHFDS TIPTTIFDIQ
SLSLEDQNLE IERFMREEKW RKFDWTKAPF LRLALHKRSA DQSQFTFSHP LFDGWSMGLL
ITEFFTIYGA LLKDKKPPLK PAPQVKYRDF LSLERQTMRS EASLHYWQRK LAGISRSELP
RWPAHRKEGP GRHIRVVVKV PSATLKGLQK LATVAEVPFK TVLLAAHMRV VGFLTGSTEV
TTGLLTNGRP EMLDADSVIG MFLNTTPFHI NLDSKNWIEL ARNTFQAESE LLPHRRFPLA
ELVRIVGDGK QLFETAFNYI HFHIYKALEK VPDLSVLSWK SPSDQTYFPL TAYFHLDISQ
ESSELLFFLD VDTGVLAQQQ IDSLPHYYLN TLKAMASDHN AEYKAIQLLP CEEQKLIIED
LNKTTDLTAK STLLVHQAFS FQARLQDEKI AVLCHKGQLS YKELEQRSNC LAHYLHGLGV
GSNRLVAVCL QRSTNLIVAL LAVLKAGGAY VPLDPLYPKE RLAYMLDDAQ TTVILTETFS
CDNLPEGAFR KIFLDTEWPA ISRFPDLPAD FVQDKEDLAY VIYTSGSTGL PKGVEIPHRA
LSNFLSSINS LLAWQPSEKL LALTTISFDI AGLEIFLPLI TGAQVYLASK EISVDGEGLA
QLITKEKITS IQATPATWRM LIDTGWTGHA GLRALCGGER MPQELARDLL DRGCDLWNLY
GPTETTIWST LWHVESMEDL IPIGKPLGNT NIYVLDEFQR PVPLGVPGEL YISGLGVARG
YRNLPELTAE RFSTDPFSGQ NYRMYRTGDL VRFRPDGVLE YLSRVDQQVK VRGFRIELGE
IETHLNSLEG IDKAITRIMD DGFGENHIVA YCLQNGKIAY TTSQLRQLLL EKLPSYMVPS
NFVFLEQFPL TLNGKIDFKA LPKPEISRQP LQDAYTAPRS ELEQKIAEIY AELLRVERVG
IDDNFFDMGG HSLLLVRIHG QLQALFERKI PIVKLFELPT VRKVATLFAS QDEQLVVAEA
GERANKRKDW LVKQQKRRYS GIPKLEKT
//
