ID A0A0W0Y539_9GAMM Unreviewed; 365 AA.
AC A0A0W0Y539;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Polyketide biosynthesis 3-hydroxy-3-methylglutaryl-ACP synthase PksG {ECO:0000313|EMBL:KTD51619.1};
DE EC=2.3.3.- {ECO:0000313|EMBL:KTD51619.1};
GN Name=pksG {ECO:0000313|EMBL:KTD51619.1};
GN ORFNames=Lqui_0463 {ECO:0000313|EMBL:KTD51619.1};
OS Legionella quinlivanii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=45073 {ECO:0000313|EMBL:KTD51619.1, ECO:0000313|Proteomes:UP000054618};
RN [1] {ECO:0000313|EMBL:KTD51619.1, ECO:0000313|Proteomes:UP000054618}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC#1442-AUS-E {ECO:0000313|EMBL:KTD51619.1,
RC ECO:0000313|Proteomes:UP000054618};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC family. {ECO:0000256|ARBA:ARBA00007061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD51619.1}.
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DR EMBL; LNYS01000006; KTD51619.1; -; Genomic_DNA.
DR RefSeq; WP_058506586.1; NZ_UGOX01000001.1.
DR AlphaFoldDB; A0A0W0Y539; -.
DR STRING; 45073.Lqui_0463; -.
DR PATRIC; fig|45073.5.peg.492; -.
DR OrthoDB; 9769523at2; -.
DR Proteomes; UP000054618; Unassembled WGS sequence.
DR GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR CDD; cd00827; init_cond_enzymes; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR InterPro; IPR013528; HMG_CoA_synth_N.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF08540; HMG_CoA_synt_C; 2.
DR Pfam; PF01154; HMG_CoA_synt_N; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:KTD51619.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054618};
KW Transferase {ECO:0000313|EMBL:KTD51619.1}.
FT DOMAIN 4..171
FT /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01154"
FT DOMAIN 183..253
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
FT DOMAIN 267..358
FT /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08540"
SQ SEQUENCE 365 AA; 40355 MW; F0E66F933A93B561 CRC64;
MSSSVGITSI GISFPPFYMH LNELARLRGV EAEKYTKGLG LNEMALCGNQ YTVIDLAIQA
AQDAIKRWGG SVEDIGLIAV GTETPVDYSR PLSAWVASEL KIQGYVRSYE VKHACYGGTL
ALLQAAEWYQ ANPDKQKVAL VIAVDEALYA QNDPGEPTQG AGAVAFIVGP ANLATINVGH
TIAYSEPVFD FWKPLDKHYP EVNGQFSLEC YKQAAVSCYK KMVKDENPVD FLNRYSALCF
HVPFPKMVYK AFNAVGESLG FDAAQINELY EQRVNPFMTW NQRCGNAYTA SLWIMFAYAL
AHTPPDSRLL LFSYGSGMGS ELIECVNNSD DGYREWAAKV EEQLNQRQAL AAKDYAAIRE
TKPAE
//
