ID A0A0W0YSZ2_9GAMM Unreviewed; 357 AA.
AC A0A0W0YSZ2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Multidrug efflux system {ECO:0000313|EMBL:KTD60018.1};
GN Name=emrA {ECO:0000313|EMBL:KTD60018.1};
GN ORFNames=Lsha_1768 {ECO:0000313|EMBL:KTD60018.1};
OS Legionella shakespearei DSM 23087.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1122169 {ECO:0000313|EMBL:KTD60018.1, ECO:0000313|Proteomes:UP000054600};
RN [1] {ECO:0000313|EMBL:KTD60018.1, ECO:0000313|Proteomes:UP000054600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49655 {ECO:0000313|EMBL:KTD60018.1,
RC ECO:0000313|Proteomes:UP000054600};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD60018.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LNYW01000046; KTD60018.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0YSZ2; -.
DR STRING; 1122169.Lsha_1768; -.
DR PATRIC; fig|1122169.6.peg.2028; -.
DR eggNOG; COG1566; Bacteria.
DR Proteomes; UP000054600; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054600};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..109
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 217..297
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 357 AA; 39283 MW; 6EFBF5A82F440D57 CRC64;
MNELQEASTT TPIVVAPEEQ PRSKRLMLLV GVPAFALLVI TMMYLMGGRY VETENAYVKA
DKIPISSQVS GVIQETLVRE NQNVTKGQLL YRLDQEPFKV ALAKAESKLS QVRIDILALK
ASYREKQAEI DLARTKYNFS LRNKQRQTDL AAKHFTSMSS LDDAKEGAEI AAQQVTTVQY
DLKRLAESLA GSVNEPVEKH PSYLMAKAEL DQAKLDLAHT EIRAPISGTI NAPPKPGQFI
GAGNITMTLV TNDHPWVEAN FTEKELTNVR PGQQVIATID LYPGKKWKGV VESLSPATGS
EFSIIPAQNA TGNWVKIAQR VAVRIKLIPE AGSPQLRSGL SSWVKIDTKD TNTAKTT
//
