ID A0A0W0YVB7_9GAMM Unreviewed; 2116 AA.
AC A0A0W0YVB7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Polyketide synthase, type I {ECO:0008006|Google:ProtNLM};
GN ORFNames=Lsha_1529 {ECO:0000313|EMBL:KTD60812.1};
OS Legionella shakespearei DSM 23087.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1122169 {ECO:0000313|EMBL:KTD60812.1, ECO:0000313|Proteomes:UP000054600};
RN [1] {ECO:0000313|EMBL:KTD60812.1, ECO:0000313|Proteomes:UP000054600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49655 {ECO:0000313|EMBL:KTD60812.1,
RC ECO:0000313|Proteomes:UP000054600};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD60812.1}.
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DR EMBL; LNYW01000043; KTD60812.1; -; Genomic_DNA.
DR RefSeq; WP_018577277.1; NZ_LNYW01000043.1.
DR STRING; 1122169.Lsha_1529; -.
DR PATRIC; fig|1122169.6.peg.1760; -.
DR eggNOG; COG3321; Bacteria.
DR OrthoDB; 9778690at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000054600; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054600};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 420..509
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 545..956
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1468..1545
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1572..1975
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2116 AA; 233043 MW; 0136551B9C29C3E0 CRC64;
MNFERRSTQA YHLIGAEQLR IENGVYPRDY LHLIVKDDVD AFNMSSDTYE LSLNRQLAPL
WNALERFLAH GGSRIAIELR DLKGTWQQQA SFVYHLLKNV GTHYCELLLI DDEPNVFSGL
LTGAVTAFSH EAQVKIARVT AQNSDVLNVL PSLFHHCFSS EQLGHYHFGN NTLSFSSWQP
LTATASTSQS FSGNVLITGG AGAIGQLLAE HLYKQHHCQV FLTGRKPLSA ERAANLKQIK
AKAYFQADCT QFEEMQDIVH YINNQYGALN HIIHLAGNLN DSLFVNKEES IFLNTIEVKL
AGAQVIARLA EQFKPHSVTL FSSLSAVTGN IGQTDYAAAN ASLNELARRH NGKNRTQWSS
INWGLWETEQ GMQMPDSASM LPMKSEEALA LLDLIHANNL VVTTVYNGTD QLLNPGHKTE
SAVSSQAQLA TDKARKRLKE IIVECTKIKN LDDDVSLLEK GVDSIIATHI AIHIEKELTQ
SGAACKIPKT LIFQHASVNQ IFAYLMENHL AALQSVFPDS TIQVATNEKQ HELRVPETAK
PSEDNDHFAI VAAAGEFPEA VDLHEFWELI KNGSNAIKPI PKQRWDWQEQ FSLDEKGKSY
CRQGGFIREA ALFDNAYFKI TPRDAQKMTP EARRLLHQSY YALEQCNFLK SLEGNVAVFV
ANMYAHYQNL NKENELVDSS LSAMANHISY AFGFNGASMG VDSMCSGGLN ALHIALNSLK
LHDCNAVLVG AANIMSHPGK YRFLSENKFL SPSGKCQSFG IAADGYVPGE GCVVLVIKRL
NDAKAANDKI LGVIRGSAIN SNGAHSAMTV PSATAQAQVI KKALDKSGLN PEDISYIETH
GTGTSLGDPI EISGLNQVYG QNNNSIAIGS LKSNIGHLEA AAGLASVVKV LLQMHYRMKV
PSIHCDIENP LLGLEQTPFV IQKNVSPWGN DEEQVVYAGV SAFGAGGANG HVILQSPPRQ
YAYDELPRAK NKLKGTQPFW IDLQSGVGKI KHAAQAVQIE KDKALWMTKK TELCDSPLVS
VYEEVETLFL VTAAQKQILF AQQKQCLLLD DAAFQLDAIF QQQPHKKYVV VNLTALGESE
DDSYLLKHFD FSKSLTAKKI HLDLILVSPL GHQSISVCRR AAIDGLYRTL KLEHSTINTL
VMQSDDSISQ IAELVQTCQI KEGVSGIYQY NHGHTSSAVA RNLMAVSDGQ WQRQVFGENE
ELIQDSHAPL LKEGGVYIIS GGLGALGQIV SKCLLRQYNA RVICLGRSAL TGTKWDQFQQ
LKAINPHVAY YQADITDSVA LSKVITEIIG QYGQVNGVIN SACVLNDGLL REKSFSAFSE
VIKSKIQGTE TLDEVTKELA LDFFVSFSSM SAVYSNVGQA DYCMANTFVD YFTDYREGLV
NKGLRQGKSM TLNWPLWEVD GLSLSKQTIA FLCEATGIDP LNEQQGAQLF QRLLDKKHPA
QIIPLQGNKK NIRAKLLMKQ SVDRVTERSL DDLTASVIAA LSEVTHQNPA TLTPETGINE
LGMSSVLLTE LAGLLEKKSG VPIAPSAFFS YNSVLKIAQY LNQKMPQQKV DAVSHAPVVR
VDMRTDLSED NNNEFAIIGF SALLPGSSDS EPFWDMLLQN KSAVRQVSRW DGEYFAATLD
DIRQFDNQFF NLSNREAMLM DPQHRLFLQE SYKALLDAGY PPATMKAVGV FAGVQFNDYQ
TLLSKNNIAQ HPYMATGNSH AMLANRVSYL FDFNGPSQTV DTACSSTLIA VNRGILALKN
NECELALCGA VSLLIDSGVT EAAKSMGVLS PNYRCATFDE QADGYVRGEG AGVFVIKRLK
DALRDKDAIH AVITACAENH GGKANSLTAP NPAAQKELLL KAYTPALAGQ VSYIETHGTG
TKLGDPIEID ALTQAFTELL PDAAKNSILL GSVKTNVGHL EPAAGVASMV KVICALKHGI
IPANLHFNTL NPYIDLHNSP FKIVAENTPW DKQERVAGIS SFGFGGSYAH VVLRQAPAST
VSPSRQAECY FPLSARKPQL LQLMKKELLA FLTKEKDCSA EALSYMLTCR REHFRHRFIC
KCSSLDELMR HLQTDDAVTL LEDEVMHSFM AGKDVVWEQH FSEQITKLHI PGYVFEQKEF
WFDSSITESV VELAHE
//
