ID A0A0W0YVY5_9GAMM Unreviewed; 1967 AA.
AC A0A0W0YVY5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Non-ribosomal peptide synthetase/polyketide synthetase {ECO:0000313|EMBL:KTD60814.1};
DE EC=5.1.1.11 {ECO:0000313|EMBL:KTD60814.1};
GN ORFNames=Lsha_1531 {ECO:0000313|EMBL:KTD60814.1};
OS Legionella shakespearei DSM 23087.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1122169 {ECO:0000313|EMBL:KTD60814.1, ECO:0000313|Proteomes:UP000054600};
RN [1] {ECO:0000313|EMBL:KTD60814.1, ECO:0000313|Proteomes:UP000054600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49655 {ECO:0000313|EMBL:KTD60814.1,
RC ECO:0000313|Proteomes:UP000054600};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD60814.1}.
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DR EMBL; LNYW01000043; KTD60814.1; -; Genomic_DNA.
DR STRING; 1122169.Lsha_1531; -.
DR PATRIC; fig|1122169.6.peg.1762; -.
DR eggNOG; COG1020; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR Proteomes; UP000054600; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0047462; F:phenylalanine racemase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:KTD60814.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054600};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1049..1124
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1142..1549
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 647..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1967 AA; 219366 MW; FE933703DBB3681C CRC64;
MLDTMTLKAE AGEQLIWNRL LQNPEDKSCT LSYRFLINQV LSHEQINAAV YSLLRQHPEL
NYRFYAHDGV LYKRLHQPSL NPVTRIDGHS LVEKVLFCET LNPLYCFQWQ VQEGGFYLYV
HLSHLIIDGS GFALLVSELE AAFSGAQKSH SELGSLDTAD KPRYGGVSHH LIAVSKATGD
ALDTPPSRGL STGSRNLASD LDPWIPRTSR GTVECQDALT ATNLSDTPPS RGLSTGSSNL
TSDLDPWIPR TSCGTAESSY WQEYLQGQSL YQSLPFLEHG GQEVLVHYEL AIQPELVKQI
GEYRKNNKAT LFHLISTALA ITLHHYIKDE DLETTIRLAY YVKLNKKLDK FGCDINLLPL
FVPCNEQASL QQILQTVIAV RSEQKERQHT PLAELLPYLD PARNTNLPLM NVVINESPGL
LPQVTSGFIS EATGIENHSA ATTLSLVYAF DGEHLRLQFE SAQSMGLQVL LRQLASHFEQ
VLTILVTQPQ TLLADLLFRE PFAPVCQGES FTYEKDTLWD TFARQMHEHQ TRIAISDEQH
SLSYEQTHSI ITAIYEQLQP LDKEELANGI AVFLSRTALL PLAMLAALMA RVTFIPVAEN
IPEGGRHAIL NETKSQIIFV DNQSEALLSA TEKETLRVIN IESELRNPSR DRQEAEPLDI
RINKGINTDA SNPSAPSRSR LGLDQKILPL LQNDIAYILF TSGSTGKPKG VMITYDNLTN
FLYSVSSNPG FTQHDRMLAL TSISFDISIN ELLLPLFCGG SVFVAANSVR SCHKSLGNRL
NQEYVSVLQA TPSTLSLLMQ SGWVWHNKNK LRLWIGGEAL TADLVRFFKG QNIDIYNMYG
PTEATIWVSA TQIHSPDVLS IGRPLANTSL YVLDKHGQAM PLGIPGELVI EGDLVGMGYI
NHPSTSFKQS DSGLRRYHTG DKVLALANNT LLYLKRYDDQ VKLRGYRIEL EEINQQIRTL
VPHFIGLTLA LYEPEPHLCV YYTSPADLNV AQLKAQLQRV FPEYKIPQRY QLISAMPLNN
NGKIDRKRLM EAKRDDVPVA AELSRHKSSE WNPAEQQIVA LIAQHFAVTI TSRDHSLLDY
GFNSLSFNQL SLLCDKELGL TISSHQFYHL NTLNKLAQYY VLNKSIHTPI TAPASSGQIQ
AHMPVAIIGY DAVLPGGKTP AEFWHLLINQ ECLISEHKRP WLHGRERAAY VRDIECFDRK
FFNLSPIEVM HMDFRQRLLL QCAFRTMEHA GIPFNSQSPQ QIACFIAATG MDSLLASAKQ
EIPAHPYTLS GNSLSMLANR LSFYFNWQGP SVTVDTACSG SLAALARGVE CLALGKAEQC
FVGSANLIID SEFTSALQAG RFLSPQYHCA SFSDQADGYV RGEGIFGFLL KPLDKAIRDG
DSIHAVIHQV SENHGGRAAS LTSPSQQAQT SLLTAAYTPQ LAQQLSYIET HGTGTKLGDP
IEIDALKEFE RLSLAKNSHQ AVYLGALKQN IGHLEASAGF ASLLKVILAM KHKCLPANYN
NGLLNPLIKW DNSKLKLLTE TIPWEHESLT AGISSFGFGG SNAHVVLSHH ADNKLRSDSD
ETALPILLSA KTRNALRARI ISLLGDLAED LCFKDVAYTL AMGRTHFDCR TAVVAKNRQE
LVRKLNDLLH TEDLRSSLET DGVLDDYLAG KNCDWQPVFA ALDCKRISLS PYVFDAEPCL
HELFQHSSDL DLMADLGWLK ISEHQRKITL SKNHPFLAQH QVFNNRVLPG VTYIDFLLRE
LRQQRPEQNS FCLENICWLQ PAVCEGDSLT LILETIQHQD AITFQFCNSE RQVLATGQYT
ELKQDYASLY SWFEPSRNEL KRVGLDTVAA DAVYKKFSQL GIDYGSYFQG ISSVTLYENM
ALTRLALNPQ GGCTALLDAS FQSGMAINLA ESLPGLMPFS LGKMIIFNHS KLIRLEKAFV
YTLKNSPFRT NFIICDEQDE PIVALIDLGV KPSQLKFTGV VARISEA
//
