ID A0A0W0Z748_9GAMM Unreviewed; 414 AA.
AC A0A0W0Z748;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Multidrug efflux system, subunit A {ECO:0000313|EMBL:KTD64949.1};
GN Name=mdtA {ECO:0000313|EMBL:KTD64949.1};
GN ORFNames=Lsha_0318 {ECO:0000313|EMBL:KTD64949.1};
OS Legionella shakespearei DSM 23087.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=1122169 {ECO:0000313|EMBL:KTD64949.1, ECO:0000313|Proteomes:UP000054600};
RN [1] {ECO:0000313|EMBL:KTD64949.1, ECO:0000313|Proteomes:UP000054600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49655 {ECO:0000313|EMBL:KTD64949.1,
RC ECO:0000313|Proteomes:UP000054600};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD64949.1}.
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DR EMBL; LNYW01000016; KTD64949.1; -; Genomic_DNA.
DR RefSeq; WP_018575837.1; NZ_LNYW01000016.1.
DR AlphaFoldDB; A0A0W0Z748; -.
DR STRING; 1122169.Lsha_0318; -.
DR PATRIC; fig|1122169.6.peg.355; -.
DR eggNOG; COG0845; Bacteria.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000054600; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054600};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..310
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 414 AA; 45527 MW; 0ABC4C016D7AB534 CRC64;
MDANDASDAG EKASIQTKQQ LKKPYTSSDF WLIVSLIVMV LSLIWFFYAM RQPKENSPKP
LAVVSAKATS RDVPVYLSAL GNVTPTYKVT VKTQINGILQ QVLFKEGQLV KTGDLLAQID
PRPYEALLTQ YEGNLKRDKA LLANAKIDLK RYQTLWRQDS IAQQTLATQQ ALVEQYEGAI
KIDEGLIQST KVSLIYCRII SPIDGRIGLR LVDAGNVVQT GDTTGLAEIT TLNPITVIFA
LPEDNVPQII PQVYADKTLE VQAYDRQQNK LLATGTLLTI DNHIDPSTGT VRLRATFDNK
ENTLFPNQFV NVKLLVQTLT KATLVPTQAI QHHLASDFVY LLRPDQTVTV QPVVAGPASG
NETVIMQGLK PGQEVITEGT DKLKDGAKVE VQKPSSALVP VQTSLKHSVT RSVV
//
