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Database: UniProt
Entry: A0A0W0ZVK5_9GAMM
LinkDB: A0A0W0ZVK5_9GAMM
Original site: A0A0W0ZVK5_9GAMM 
ID   A0A0W0ZVK5_9GAMM        Unreviewed;       734 AA.
AC   A0A0W0ZVK5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE   AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE   AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE   AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN   Name=relA {ECO:0000313|EMBL:KTD73197.1};
GN   ORFNames=Ltuc_1044 {ECO:0000313|EMBL:KTD73197.1};
OS   Legionella tucsonensis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=40335 {ECO:0000313|EMBL:KTD73197.1, ECO:0000313|Proteomes:UP000054693};
RN   [1] {ECO:0000313|EMBL:KTD73197.1, ECO:0000313|Proteomes:UP000054693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49180 {ECO:0000313|EMBL:KTD73197.1,
RC   ECO:0000313|Proteomes:UP000054693};
RA   Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA   Pupko T., Shuman H.A., Segal G.;
RT   "Genomic analysis of 38 Legionella species identifies large and diverse
RT   effector repertoires.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC       is a mediator of the stringent response that coordinates a variety of
CC       cellular activities in response to changes in nutritional abundance.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC   -!- SIMILARITY: Belongs to the relA/spoT family.
CC       {ECO:0000256|RuleBase:RU003847}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KTD73197.1}.
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DR   EMBL; LNZA01000001; KTD73197.1; -; Genomic_DNA.
DR   RefSeq; WP_058520257.1; NZ_LNZA01000001.1.
DR   AlphaFoldDB; A0A0W0ZVK5; -.
DR   STRING; 40335.Ltuc_1044; -.
DR   PATRIC; fig|40335.7.peg.1098; -.
DR   OrthoDB; 9805041at2; -.
DR   Proteomes; UP000054693; Unassembled WGS sequence.
DR   GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04876; ACT_RelA-SpoT; 1.
DR   CDD; cd05399; NT_Rel-Spo_like; 1.
DR   CDD; cd01668; TGS_RSH; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR004811; RelA/Spo_fam.
DR   InterPro; IPR007685; RelA_SpoT.
DR   InterPro; IPR004095; TGS.
DR   InterPro; IPR012676; TGS-like.
DR   InterPro; IPR033655; TGS_RelA/SpoT.
DR   NCBIfam; TIGR00691; spoT_relA; 1.
DR   PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR   PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR   Pfam; PF13291; ACT_4; 1.
DR   Pfam; PF13328; HD_4; 1.
DR   Pfam; PF04607; RelA_SpoT; 1.
DR   Pfam; PF02824; TGS; 1.
DR   SMART; SM00954; RelA_SpoT; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81271; TGS-like; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS51880; TGS; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:KTD73197.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054693};
KW   Transferase {ECO:0000313|EMBL:KTD73197.1}.
FT   DOMAIN          407..468
FT                   /note="TGS"
FT                   /evidence="ECO:0000259|PROSITE:PS51880"
FT   DOMAIN          660..734
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   734 AA;  83051 MW;  61A465387B30BCE2 CRC64;
     MVRVKDTIPL CEDGSIDVDL WLHQLGAKGY LNNLELIRSA CTLSQLAGQE HATETGQSCL
     QQGLSMADLL ADLEVDQETL AAAIIFENVH YADLSIDDVV EQLGPNIAKL VKGIERMSAM
     HSFQGLNKYP QNKQQIDNLR KMLLAMVDDV RVVLIKLAER LCVLRTAGHL SEELRKQLAT
     EAMEIYAPLA NRLGIGAIKW EMEDLAFRHM HPEDYKAIAK GLKAKRLERD NFVNAIVAQL
     NEQIKASGID HFAVYGRSKH IHSIYKKMTR KNVSLDEIYD ATAVRVLVNT QPQCYEVLGM
     VHTLWKQIPA EFDDYIINPK PNGYQSLHTA VKGPEGRVFE VQIRTFHMHD LAEMGVAAHW
     KYKEGGFKQK QSHERKIEWL RDVLAWHREM ASNKGVPEST TTEFLEDRVY VFTPDGDVLD
     LPHGVTPLDF AYHVHSDLGH RCRGARINGH IAPLTYQLKT GDRVEILAGK ESKPSRDWIN
     PHLNYLKTSR AKAKVLHWFK MQDYDRNIQD GRELLDKELK SLGIKSDKLN EAAAALHFKK
     LDDLYANLGR GDIKIGQIIS KLTPPTTSEL NLERFVRPQA KPEITGSDLR IEGVGNLLTF
     MARCCQPVPG DPVIGYITIG RGVSVHRQDC PNIIHANERQ KQRFLQVTWG SATRENYVVD
     ILIKAFDRSE LLKDVTSLLA NEKAHVYALQ TQSNKQENMA YITLTVDVDG LSSLSRLLTK
     LEQIPNVLEA RRQV
//
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