ID A0A0W1DPN1_9SPHN Unreviewed; 1164 AA.
AC A0A0W1DPN1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ATE67_11890 {ECO:0000313|EMBL:KTE20080.1};
OS Sphingopyxis sp. H050.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingopyxis.
OX NCBI_TaxID=1759072 {ECO:0000313|EMBL:KTE20080.1, ECO:0000313|Proteomes:UP000053439};
RN [1] {ECO:0000313|Proteomes:UP000053439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H050 {ECO:0000313|Proteomes:UP000053439};
RA Gomez-Alvarez V., Revetta R.P.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTE20080.1}.
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DR EMBL; LNRZ01000005; KTE20080.1; -; Genomic_DNA.
DR RefSeq; WP_058816888.1; NZ_LNRZ01000005.1.
DR AlphaFoldDB; A0A0W1DPN1; -.
DR STRING; 1759072.ATE67_11890; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000053439; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 629..790
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 811..965
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1164 AA; 126866 MW; EFA1A57533946479 CRC64;
MTRPAADIFA AIASAPAPLT LARAADGFLP LLLADLARAS DTRLVYVATD DAAMQAVADA
APFFAPDLSV HRFPAWDCLP YDRAGPSMRI SADRLATLSA LQAPPKRGEL ILTTVAAITQ
RTLTPFRIRQ LATTLAAGQR IDRDALAELL VSNGFSRVDT VADQGEFAVR GGILDLFPAG
EETGLRVDFF GDEIESIRRF DPADQRSLGP AKALQLLPAA ETLLDESTIK RFRSSYREIF
GAQATGDPLY QAVSEGRRQA GMDHWLPLFE ERLATLFDHI DPATPVLRGH RTDATAETRF
DAITDYHANR VAAEREQAGS YRPLAPETLY LTRDEWADAE RTRPVHVVSP FDVPPSASVI
DLESFAARDF TPERTADLNV YDKVADHLSD ERRKGRRTII ASYSGGARER LSGLLRDHGV
TSLAPADSWQ DALGTASSES GGATAMVVLP LDHGFASDAI SLLTEQDILG ERLVRRSKRR
KSADAFLAEL ATLSVGDLVV HLDHGIGRYE GLTQIPVGSS PHDCVALTYA GGDKLYVPVE
NLDVLSRYGG ESEGVALDRL GGEAWQRRKA RMKERIREIA GELLATAAQR ALRPGEVLAQ
DAAYPAFADR FPYQETDDQD RAIGEVLEDL ASGRPMDRLV CGDVGFGKTE VALRAAFVAA
MAGVQVAVVV PTTLLARQHY TNFVERFKGF PVNIGRLSRL VPANEAQKTR DGLASGQIDI
VIGTHAVIAK SVEFKHLGLV IVDEEQRFGV VHKERLKQLK ADVHVLTLTA TPIPRTLQMA
MSGLRELSVI QTPPVDRLAV RTYVAPWDPV VMREALLREH DRGGQSFFVV PRIKDLPDIE
EFLRNRVPEI KYVVAHGQMT PTEVEDRMSA FYDRKYDVLL STTIVESGLD IPSANTLIIH
RADRFGLAQL YQLRGRVGRA KTRAYAYLTT PEGGAITDTA EKRLKLLGDL DTLGAGFQLA
SHDLDIRGAG NLVGDEQSGH IREVGFELYQ SMLEEAILAA KAEGMGAAPP REALSPVITV
DAPILIPEDY VPDLPLRMAL YRRLNEADDR PALDAFAAEM IDRFGPLPPE TANLIQLMEI
KANAKTAGIA KLDVGTKGAL VSFHGDAFAN VPGLIAYVER LKGRARIRPD NKLSISGDWA
STGARLNGAL QLSKGLGKLA RQVA
//