ID A0A0W1RII2_9EURY Unreviewed; 1033 AA.
AC A0A0W1RII2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
DE Flags: Fragment;
GN ORFNames=AUR66_19465 {ECO:0000313|EMBL:KTG13387.1};
OS Haloferax profundi.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=1544718 {ECO:0000313|EMBL:KTG13387.1, ECO:0000313|Proteomes:UP000053157};
RN [1] {ECO:0000313|EMBL:KTG13387.1, ECO:0000313|Proteomes:UP000053157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB29 {ECO:0000313|EMBL:KTG13387.1,
RC ECO:0000313|Proteomes:UP000053157};
RA Zhang G., Stingl U., Rashid M.;
RT "Haloferax profundi sp. nov. isolated from the Discovery deep brine-
RT seawater interface in the Red Sea.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTG13387.1}.
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DR EMBL; LOPV01000599; KTG13387.1; -; Genomic_DNA.
DR RefSeq; WP_058573447.1; NZ_LOPV01000599.1.
DR AlphaFoldDB; A0A0W1RII2; -.
DR OrthoDB; 45790at2157; -.
DR Proteomes; UP000053157; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 367..629
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 680..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KTG13387.1"
SQ SEQUENCE 1033 AA; 116536 MW; 86BED31F96CF24F4 CRC64;
LARAGDFRVL YVELSELTRT AERDFVQCLT HARLGTDWAT EDTFLAVFHA PDSTAWHLVT
PFRTGVDDGR TGRPVLRRYT LGAGQTHRHV SDALAKIGAH DGQLADRIDE AFQVDTLTEE
FYDDYKWAFE RLSDDLRESG VDTKDVHQYA HVTLTRLLCF YYLQRRGWTG GRTDFVRWFH
DRYRASGEDE QFHETWLSAL FFSESDHPEG TSPFTSLPDE VEAARTECPP LNDGLFEPTD
ADRSEWYFSD SALTSVICDF LERYTYTISE ESSYDVDVAV DPSMLGKIYE SFVAEEDRDE
AGIFYTPRAE VDLMCRLALY EQFCDQIERP DTARKRALVE FLFSTPSGWD RTKIDIDDEL
EAVLRNLRIV DPACGSGAFL VGMGQVLTEL FEKVGLTVDA ELKSRILDEA LYGADIKPWA
VRVAAFRLWL WVVETEPEIP PEEFELLDFS FNLYTGDSVV GREGDGLDAA QEDGFDVVIT
NPPYVDHQHI AQQNHPQTVS DQSPPADVRS SKAAYKTALV TYVQETFGIK PYRSSDLYLY
FFFRAIDLLR DGGTLMFLTS NTWLDTAYGK RLQQGLLELT DIECIVDNRK RRSFERASVN
TVLTVANRTS ERSLAGEVKF VALSDPYERV VSPPTMADIL VDSSEDEGTD EFALGSERGR
IRRLDAIRVV RLDEPALWRL GGGTTQPRRE RGTGTSRTST PVCPGGTYTG TSWGRFLRAP
SAYFDVLEAG ADIFTPLSSI ASVGSYLNTG GADGFFFVTL EEGDPQTDRH VTIRNRETDE
TFTVESAFVV PFVESPRQVT HVDLSNDEFE SYLVSIPMGT DLSDTHVQRY VAWGERRGAY
HTASGRRGKR EWWEIGTRGE TNTTVVWPNR QHDRHFVAYN PNRTVTHRFY RLAPHDAADV
TPEELAALLN FSPTALFTEV LASTGLGLGV LDVTGRTLQQ IPVVDPAKLS KSSLETIRGA
FRRMANRPMG SMHDELGATT AEQFDIDAVV SDRRTIDREL FEQYLDVAPS EQVPIYQAIL
ETVNTRINKS RSL
//
