ID A0A0W1S5U8_9EURY Unreviewed; 665 AA.
AC A0A0W1S5U8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN ORFNames=AUR66_17145 {ECO:0000313|EMBL:KTG21473.1};
OS Haloferax profundi.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=1544718 {ECO:0000313|EMBL:KTG21473.1, ECO:0000313|Proteomes:UP000053157};
RN [1] {ECO:0000313|EMBL:KTG21473.1, ECO:0000313|Proteomes:UP000053157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB29 {ECO:0000313|EMBL:KTG21473.1,
RC ECO:0000313|Proteomes:UP000053157};
RA Zhang G., Stingl U., Rashid M.;
RT "Haloferax profundi sp. nov. isolated from the Discovery deep brine-
RT seawater interface in the Red Sea.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTG21473.1}.
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DR EMBL; LOPV01000390; KTG21473.1; -; Genomic_DNA.
DR RefSeq; WP_058572873.1; NZ_LOPV01000390.1.
DR AlphaFoldDB; A0A0W1S5U8; -.
DR OrthoDB; 371752at2157; -.
DR Proteomes; UP000053157; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 35..87
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 94..478
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 548..626
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 665 AA; 74499 MW; 01699670E70E0E53 CRC64;
MTDETQVELE ARLAEQEVFE PSEEFVAQAN VSDPDIYEEF EENWPGCWEQ AAEMLDWDDD
YDQVLDDSNP PFYEWFTGGK LNASYNCLDR HVENGDKNRV AIKWEGEHGE TRTYTYQDLY
REVNEFAAAL RAQGVEEDDV VTLYMPMVPE LPIAMLACAR IGAPHSVVFA GFSAEALATR
MNSADSRCLV TCDGYYRRGD ALDHLDKANE GLDSVDHGVD AVVVVDRLGD DGFDHELKGN
QHDWDDLMDE HAGERVDPVQ RDAEDMLFLM YTSGTTGQPK GVKHTTGGYL SYAAWTSHAV
LDIEKEDTYW CSADIGWITG HSYIVYGPLA LGSTTVMYEG TPDFPNRDRL WDIIEKYAVD
IFYTAPTAIR AFMKWGSQFP EQHDLSSLRL LGTVGEPINP RAWKWYYKHI GNEECPVVDT
WWQTETGGMM VTTLPGVCDM KPGSAGPPLP GIDAQIVDTN GEEVDAGRAG YLTVNKPWPG
MLRTLYKNDE RFIQEYWQEY SDTDSDDASD WVYFPEDGAK VDDDGYITVL GRVDDVINVS
GHRLGTMEIE SAIVGVEGVA EAAVVGAKHD LKGEAVYAYV ITEDGAEGND ELRSRIIEGV
EDAIGPIARP EEVIFTPELP KTRSGKIMRR LLEDVANGEE LGNTSTLRNP EIVEEIEQKV
QQQRN
//
