ID A0A0W1S982_9EURY Unreviewed; 435 AA.
AC A0A0W1S982;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Carboxypeptidase Q {ECO:0000256|ARBA:ARBA00014116};
DE AltName: Full=Plasma glutamate carboxypeptidase {ECO:0000256|ARBA:ARBA00033328};
GN ORFNames=AUR66_01745 {ECO:0000313|EMBL:KTG22508.1};
OS Haloferax profundi.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Haloferacaceae; Haloferax.
OX NCBI_TaxID=1544718 {ECO:0000313|EMBL:KTG22508.1, ECO:0000313|Proteomes:UP000053157};
RN [1] {ECO:0000313|EMBL:KTG22508.1, ECO:0000313|Proteomes:UP000053157}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB29 {ECO:0000313|EMBL:KTG22508.1,
RC ECO:0000313|Proteomes:UP000053157};
RA Zhang G., Stingl U., Rashid M.;
RT "Haloferax profundi sp. nov. isolated from the Discovery deep brine-
RT seawater interface in the Red Sea.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. The monomeric form is inactive while the homodimer
CC is active. {ECO:0000256|ARBA:ARBA00025833}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus
CC {ECO:0000256|ARBA:ARBA00004555}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTG22508.1}.
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DR EMBL; LOPV01000368; KTG22508.1; -; Genomic_DNA.
DR RefSeq; WP_058572788.1; NZ_LOPV01000368.1.
DR AlphaFoldDB; A0A0W1S982; -.
DR OrthoDB; 18376at2157; -.
DR Proteomes; UP000053157; Unassembled WGS sequence.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0070573; F:metallodipeptidase activity; IEA:InterPro.
DR CDD; cd04819; PA_2; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR039866; CPQ.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12053:SF3; CARBOXYPEPTIDASE Q; 1.
DR PANTHER; PTHR12053; PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022645}.
FT DOMAIN 91..184
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 208..390
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 435 AA; 46901 MW; EC749228370ED473 CRC64;
MTDWIGDTFT SEVGWTHLET LVDIGNRMAG SPGEREAMEA TRDALESVGA RDARIDPFEI
QGWERGDSAI AAHNTRQECI ALPRSPAGAA SGELVDLGCG LPEDFDRDLS GKVVVVSSTV
PDHYDRFIHR REKYYYAVES GAAGFIFANH VPGQLPPTGS VGTAEAPIGD IPAVGVSKEV
GARLGRRFEG EEVTVEVSCE TPDADSGNVH AELGPDTDEE VLVTSHLDAH DIAEGAMDNG
AGTAMVVELA RALAAREDEL ETRVRFVCFG AEEVGLVGSE HEAERLGADR ANVKAIVNND
GVVAGRTLRL HTHGFDELDD AAKTVADRFD HDISTIPEQL PHSDHWPFVA YGVPAYMVGS
EKEGRGRGWG HTHADTIEKL ESRTLREQAI LLTELTVELA RADREIPHAD PTDIAAALEA
EDQAEGMKVT GDWPF
//
