ID A0A0W4ZBW5_PNEJ7 Unreviewed; 564 AA.
AC A0A0W4ZBW5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 35.
DE RecName: Full=Pescadillo homolog {ECO:0000256|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000256|HAMAP-Rule:MF_03028};
GN Name=NOP7 {ECO:0000256|HAMAP-Rule:MF_03028};
GN ORFNames=T551_03649 {ECO:0000313|EMBL:KTW25813.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW25813.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. Within the NOP7 complex ERB1 appears to interact directly with
CC NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000256|HAMAP-
CC Rule:MF_03028}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW25813.1}.
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DR EMBL; LFWA01000020; KTW25813.1; -; Genomic_DNA.
DR RefSeq; XP_018227860.1; XM_018375912.1.
DR AlphaFoldDB; A0A0W4ZBW5; -.
DR STRING; 1408657.A0A0W4ZBW5; -.
DR GeneID; 28942167; -.
DR VEuPathDB; FungiDB:T551_03649; -.
DR eggNOG; KOG2481; Eukaryota.
DR OrthoDB; 169151at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_03028};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03028};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03028};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03028}.
FT DOMAIN 347..440
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 459..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 535..562
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03028"
SQ SEQUENCE 564 AA; 65655 MW; BD5925C3147315B6 CRC64;
MAKIKSKGES GTAKNFITRN QALKKLQVTL ADFRRLCIFK GIYPREPRNK KKANKGSTAP
ATFYYSKDIQ YLLHEPIIDK IRQHKAFIRK FNRALSRQEY EVAKSLQRIK PSYTLDHIIK
ERYPTFLDAI RDLDDALSML FLFSSIHVTD KVDSSVILNC ERLCLEFQNY IIISKSLRKA
FLSIKGIYYQ AEIRGQDVTW LVPYKFSQEI PPDVDFRIMV TFLEFYQTFL GFVNFKLYND
FGLTYPPPVN ISLLEGAGDI LAYSLEKSRT QIENKSEENQ KPKDIKKQVI TLNKELDKIF
AETEFSTHNS EISEDINDDV VLDNFHMQSD SKDSLNKLIQ PVTPNSEKVN IFENFIFYLS
REAPRYSLEF VIRSFGGKVG WDPVLGDGSP FKEDDMAITH QIYDRPSLNK RIITRVYIQP
QWVYDCINKK KILNTDEYAP GSLLPPHLSP FVNVNDNEYN PEMEDEDDNL DDQNSSNGIL
NNHKADLQDT SLLDNIEKTE KLEIEETKSE EVKNLAKIML TSKQKKLYKK MIYSNLKKKE
EIDKLKKKRK KLMQAKKQKS NVKV
//
