ID A0A0W4ZDP3_PNEJ7 Unreviewed; 1688 AA.
AC A0A0W4ZDP3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101};
GN ORFNames=T551_03419 {ECO:0000313|EMBL:KTW26502.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW26502.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy. {ECO:0000256|ARBA:ARBA00024687,
CC ECO:0000256|RuleBase:RU364101}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the SEC16 family.
CC {ECO:0000256|ARBA:ARBA00005927, ECO:0000256|RuleBase:RU364101}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW26502.1}.
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DR EMBL; LFWA01000017; KTW26502.1; -; Genomic_DNA.
DR RefSeq; XP_018228031.1; XM_018375682.1.
DR STRING; 1408657.A0A0W4ZDP3; -.
DR GeneID; 28941937; -.
DR VEuPathDB; FungiDB:T551_03419; -.
DR eggNOG; KOG1913; Eukaryota.
DR OrthoDB; 1361743at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09233; ACE1-Sec16-like; 1.
DR Gene3D; 1.25.40.1030; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR PANTHER; PTHR13402; RGPR-RELATED; 1.
DR PANTHER; PTHR13402:SF6; SECRETORY 16, ISOFORM I; 1.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|RuleBase:RU364101};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364101};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU364101}; Membrane {ECO:0000256|RuleBase:RU364101};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU364101};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW Transport {ECO:0000256|RuleBase:RU364101}.
FT DOMAIN 835..950
FT /note="Sec16 central conserved"
FT /evidence="ECO:0000259|Pfam:PF12932"
FT DOMAIN 1014..1313
FT /note="Ancestral coatomer element 1 Sec16/Sec31"
FT /evidence="ECO:0000259|Pfam:PF12931"
FT REGION 1495..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1688 AA; 195579 MW; A3E92AF0C8AEFF6C CRC64;
MEKDIKDEKN KLEQIDPYTS QYSDTKQKID TKFIQWNSEY SEVTDISTKE FNKDNISLQS
SKKKIHEKSK ILPQFMPHQQ VTENEHFEKL NPFDINYIKN INNNNNFHRK PIFFSNEHNK
ETQNHLEMQA SDDFISNNIN KINSNIYENI SMNLAEKQGT PESAISVSET YEPSRQSIIN
LESNSINLNQ NFSKKSTIEN FNKNEENLSK NIFEEDYVSS KTVFIEELSN SKNNHTEKDM
PVNKKENNII LDLHTKFDHA STLFQTTDSD ESSFFKDISD TIIPDKNSKS HRNIIENDII
SNQTNYNDIW KTIGEDTDFL PDEIPHIKNH TNSYINNIKN GSGLKTAISN KEINSLLKNN
TEDCFNQISN ASSFYLDNPK SNETSFEKPN NTCSYNIGLQ TNILDINKLK DAPSQFLSSQ
IPTESYFSTA NLEQNETALK SYISAKGGYL SPYDLPMQII HKFKHPINPI SNKYSEIQKH
NYSLNHPETN INEPNARLYN LMQNISINKN ISDNPIMFHN DTASKSTINQ KKFQEHTPIN
TPILNINMPS IQQTFKTYEE KTEEKNKMFQ DFPLELSGNS KIQAQNIHKT LHIAHIQNSN
TRTEYPNTHF FTINQQNLKE IDQTYSENNQ NIPNIPESNF LLSNMPPSIN NPETNIQEIN
LNYFSLNSKK TQDIYEKSRI QKNTLKSNDI IDPETKVINR TNLYSQYSSV PYNSKRNISN
NEDIWDPNNK KSLEHQQSYP FTSKYEPYSP SIKQNLSPTL DFSSDTNNSY SQSEKQYDTL
MISNEYSSFG LPSHLASDIY INNSLSNGNE NSKIYNFQEK SETAYHKNDF KNTNHPILVW
GFGGKIITIF PNKINVSNNT EYMHFNSSNT FGTLKISNIR SYVEKSELLQ LMPPGPLFST
SKSTNKTYKK EAIKWMKEKI QLLEHIENYE QSFLNEKILL WKIIYVLLDN SNSPNQMETI
HLILNLLYPE LQLLNKKEHE FTITADFANH SSNINENVRE ISSYIVTQES LEQIKLYLLK
GAKDNALQFC LDKKLWSHAL LISSSMNREA WKYVVKKFIY SEIDINNKNL QSLKFFYETL
YESDSETENS IFFDKIINTQ INKIDKSCQD HLNDWKEKLA IILSNPNDKD FTIIYNLGKS
LIKNNNIIAG HICFLLARKD NAFFISDIPN SDLILIGEDH MKNSSFYCDL DNIILNEILE
LCTALRSQSP FYGYVHLQAY KFYYTAVLTD FGYISEAQKY CESINDIIKK YSKSSAFFHP
FFIQQFQEFS SRFLTCESLD SLSSWFGKKM TKPKLDSFWG SIENKLSKFV AGETGSIESQ
KNSNNDSKPF VRLAEKASLS RIHSQANFKV LNTYIATPFL MQDENIHQQN HQEKLIKTDQ
NNYKISPNLF TTNSQDHDII LKNKNYNNLT YHQSIQAFDR TSQDNSSDSD QYYKKAITLE
NDSEVILERQ SIIKENNELK QQKGDNSDYI ESMDTLTNQS YNAKSVSQDF FDTKFESQDS
SRSNHKPQNL DSLKVESQSS KKDEENKNIN SSWFSKWWGK KEQSKEKKVY KAKLGEDNSF
VYDVKLKKWI NKKDNLSTFE QNILPPPPKK TESSHSKEPV IKESQYYEEM PNKLSSISIS
QIDSTKNQLS VKSTNKPIVL DGNTLDDLLE MASKHSSTIG NAQGKLFSRK TKTKNTKDKY
VNIMNLTP
//
