ID A0A0W4ZIK3_PNEJ7 Unreviewed; 847 AA.
AC A0A0W4ZIK3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Dynamin-type G domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=T551_02623 {ECO:0000313|EMBL:KTW28204.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW28204.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW28204.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFWA01000012; KTW28204.1; -; Genomic_DNA.
DR RefSeq; XP_018228766.1; XM_018374886.1.
DR AlphaFoldDB; A0A0W4ZIK3; -.
DR STRING; 1408657.A0A0W4ZIK3; -.
DR GeneID; 28941141; -.
DR VEuPathDB; FungiDB:T551_02623; -.
DR OrthoDB; 1052588at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR019762; Dynamin_GTPase_CS.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF237; INTERFERON-INDUCED GTP-BINDING PROTEIN MX; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00410; G_DYNAMIN_1; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU003932};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447}.
FT DOMAIN 215..480
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 751..844
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 847 AA; 98227 MW; B4977147B92DEC54 CRC64;
MTLKAFIKGF SYISNIFCES LIKNGYRVKG YAKYFIFQSF VDKNIKQTLK RSNNISNDYK
YVFISRPIAF SLVSRTIYKV LKVSISGSLL FFIGINYINY KIQVGISYFK DLFDCYTIYL
KIIFEFIKQN ILSKIEAFVF KILFLRDTFL KMDKFILSLC DIMVSSITSL LSFSQKQHIE
NCVVHDIPDN SQMVLLIKRM IEIKNILQQI KQNEKFALPN IVVIGSQSSG KSSVLEAIIG
HEFLPKGTDM VTRRPIELTL VHTFGADEYG EFPDLEQKRV SFDQIQKIIT DLNYHISEND
YISEEPIKLN IFSSNVPDLT FIDLPGYIQV ESKDQPVSLK ERIIALCDKY IQEPNIILAV
SAADVDLANS AALSASRRVD PDGIRTIGVI TKMDLVTPER GYNILKSTNY PLKLGYVGVI
PTFSFYPFDK NINLTNLIAK NEKKIFSNFQ GFNNTECFGI IILRKKLVQV LESSMMHSLK
NIYDSIKSEL EETSYQLKAE YNDRYITPEI YMADLLNVLK YSFKGFIDNF GKPQIRLILK
DILNQKVLDL LAERYWTDKS MIEWSKKSSD ETYWKHKLDV STSYLTKLGI GRLVTDLLIF
VIVSEMGKLA QENQFRIHPY ISQCILQSTQ NILKENYYST VKQVENSVKP YKHEIDIDES
EWELGRERSL KILKNELKMC KDAFEKLRNS VGSKKLEEIV NLIINTKNGC ENVGYNKSLI
KKGQHAIFLR NRENILNIRL KFLKSKKCKN IVNKHYCPEI FLEIVAKKLV DIAVLFANVE
LLSEFAHKFP RDLDNRLVYN LTSEQLEKIA KENYETQKHI DLQQRKALLE LVLEKISLLM
LFERTYE
//
