ID A0A0W4ZJY9_PNEJ7 Unreviewed; 1259 AA.
AC A0A0W4ZJY9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE RecName: Full=Rho1 guanine nucleotide exchange factor 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=T551_02557 {ECO:0000313|EMBL:KTW28707.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW28707.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW28707.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFWA01000011; KTW28707.1; -; Genomic_DNA.
DR RefSeq; XP_018229042.1; XM_018374820.1.
DR AlphaFoldDB; A0A0W4ZJY9; -.
DR STRING; 1408657.A0A0W4ZJY9; -.
DR GeneID; 28941075; -.
DR VEuPathDB; FungiDB:T551_02557; -.
DR eggNOG; KOG4305; Eukaryota.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053447}.
FT DOMAIN 321..396
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 554..741
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 776..907
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 929..1227
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 144140 MW; 91B49F43026E9F4A CRC64;
MSDHYVKRSE LSNTDHHNSL FSNKKDTSMA KTSLPGAYIQ EENTSLKSNS KSEDISNGYY
DRRFCNDQFH AYPLETHIDR HCYTSTGVVS ASQHIEQSTQ LPSNIYTLNS GTSINPNRDS
SLISSSSFLK HGPHSSSLCS QKSLSSDRSF EYADHLSSYH DSSQLSEKGS RNTSEAYSDR
FLKQNTNVSE EKMHSDDRSI RYSGNDSYLL LPHHPKSCMI IRSAKNQDSL RNQAFRSDVR
GENILNKGTP YNMCFDQRFD TISTNSRMRS LYNVLVPRNE PFASYDKPKH SKSSMSSTAS
KIVKRCPVIY PALLSRVAEA FRQRIVLSDK LKDGLTYKDA FVGSEAVDII SQIIRTTDRN
LALLLGRSLD AQKFIHDVTY DHRLRDSPNE VYQFKECLSS FSDADTSIQT ESTLRNVNRT
LASETLSKTH IEDAYNDYSS INNHIVLPCS DSNTLKVSRG ILQDDSDDLP NGVFTLLTEC
YSPTCTRDQL CYSIACPRRL EQQARLNLKS LPVLKRAESR CSLNGLDDTD KQQKLWIQSV
PKDVADGLNE REKKRQEIIF EVIYTERDFV KDLEYLRDFW MKPLRNGNLI PEHRKEKFIL
AVFSNAMDVH AVNSRLAEAL TKRQQQNDVV YRIGDIFLEF LPRFDPFIRY GANQLHGKYE
FEKEKRENLV FAKFVEETER LKESRKLELN GYLTKPTTRL ARYPLLLEAV AKNTPDDNPD
KEDLMKAVKL IKEFLNKVNI ESGRAENRFN LMQLNKQLVF KSGESVDLKL SDENRRLIFK
GTLKKRNISS TSTDSSSDIQ VFLFDHVLLM VKITKREQYK VYRKPIPLEL LIISHSEDPS
ERSSVAKKSS SLLLHGASKS TPHKNDNSKG YAITFIHLGR RGYMITLFAT TSISRKKWTE
HIESQQRCLR EKSCIFKQHI ICEKYFLRGN KVACVVPYDG GRKLIYGTEN GVYVSDRKPY
SSAKVAPVRV LAINGVTQVD VLEEYSILLV LADKTLYSYP MESLDLNDTT LANKRPRKIA
GHTNFFKSGL CLGKLLVCVV KSSVLNSTIK VLEPVETISR GKKQVPFKFL LQGSQDALKV
FKEFYIPTES TSVHFLKHKL CVGSSKGFEV VNLENLETQS LLDPADTSLD FVTRKENIKP
IAIYRLNLKF LLCYDEMAFF VDKNGWATKH NWMIIWEGLP NSFALFYPYL LAFEDSFIEI
RHVETTALVQ VILGHNIRKL YDNYRECLYA YTDDDGIDKI ASLNCWETLK VQNRVSSVS
//