ID A0A0W4ZP01_PNEJ7 Unreviewed; 1247 AA.
AC A0A0W4ZP01;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Cell division control protein 25 {ECO:0008006|Google:ProtNLM};
GN ORFNames=T551_02045 {ECO:0000313|EMBL:KTW30101.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW30101.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW30101.1}.
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DR EMBL; LFWA01000008; KTW30101.1; -; Genomic_DNA.
DR RefSeq; XP_018229662.1; XM_018374308.1.
DR AlphaFoldDB; A0A0W4ZP01; -.
DR STRING; 1408657.A0A0W4ZP01; -.
DR GeneID; 28940563; -.
DR VEuPathDB; FungiDB:T551_02045; -.
DR eggNOG; KOG2070; Eukaryota.
DR eggNOG; KOG3417; Eukaryota.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 72..131
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 827..962
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 995..1230
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 1247 AA; 143857 MW; F33442317B6B6781 CRC64;
MFDSDASDTD FCANKKVSSN SKQIIEIVSD FIPKRPNSPI TTDPISETNK VEDSCYIEDK
SKWLSQDSKH RKQLSLVRAL YDFNSPELSS LKFSAGDVIE VLNKLENGWW DGILGDQRGW
FPSNYVEHLE ENEINEFNQD IVSNQKSSND DNEDDDTYSI QIGLEQSLIP KDSVECFYQK
SKNINNTLND PTWVPDIALD KQTSYLNTEI EIPETNFSPF LTYNDYSNDN LKIPKEKISL
LPIKNKKYKD LKIIPHLSKS PKNPYVKGDL IKDFNNQKKN FMEYKDSEKV QNNKKSSKEQ
LKSFAFLSQS PSVETISPLE NFIISSYENQ LDIQSLSENS ISNENSSKMS DSDDGSSVLM
PIYYRPQTPT NFKDLETTYL SCKALKLLPE ELIPSYRKIF QNMRQSINDL HKFILLNMKV
LFQKLCDSIK ITVIYLVHAS NMLRIVSMID NPFPTIISIS ENDFKTIKWY YRKILATLSR
LILSTKLASS EWLPENITSS VLNDAEDVIT IVEEYIEFII SRDSIYKTPC KIRPGFIKDR
QVGGGWKGNG LIMYTKPTVH NNMLLESKCQ SSDNLLLKPL SQELLSKLDA FLNEIKYLLN
KFQRKLLKPN FTESEKKSSI IVSEFFIIHE TQAILKSLSI FMEMIELVDV TPLGEIYGDT
YSPTLFDFLN AKQALYDSIN TLVLIVQSFP KFINMYNNDP IMSIVNSSRN LNCSLQSLMM
TIEFLVGEKE IRTKRRSEDL AHSAHLNSSQ KSSISSNISV ESNDYKTLLK TSPATPRTKT
KLKKIFGDES PFGKSPHRKA SSVFQIQNET TPWFLEHNHE GRIVYDDQGY LKAGTLMGLI
EHLTRHDLFD SLFNNTFLLT YRTLISAEDF FDLLVKRFMV APPGNLKSHE LEIWVEKKQK
PIRLRVFNIL KIWLENHFME SIDENSKKLL NRIKEFTVNI LSESIPVENL IRIIDKRIKN
EDENHFRRLI LNIGLNTPPP LLPKNLKKFK LLDLDPLEIA RQLTIIESKI YNKIKPIECL
NKAWSKNFAN DIAENIKSMI LKSNQITGWV THSILSQSEV KKRVDIIKHF INIADRCRSL
NNFSTLTSII SGINSAPIHR LKRTWELINK KTINIFDSLN KIMDSAKNFS EYRELLHVIN
PPCVPFLGVY LTDLTFIEDG NPDMIKNSKD LINFSKRIKT AEVIREIQQY QSVSYSFQIV
PEIQTYIFHC LKGMDTLGDM YDLSLGIEPR ERDDEKLTRL LQESGLL
//
