ID A0A0W4ZS08_PNEJ7 Unreviewed; 971 AA.
AC A0A0W4ZS08;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=BUB protein kinase {ECO:0008006|Google:ProtNLM};
GN ORFNames=T551_01222 {ECO:0000313|EMBL:KTW31149.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW31149.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW31149.1}.
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DR EMBL; LFWA01000005; KTW31149.1; -; Genomic_DNA.
DR RefSeq; XP_018230139.1; XM_018373485.1.
DR AlphaFoldDB; A0A0W4ZS08; -.
DR STRING; 1408657.A0A0W4ZS08; -.
DR GeneID; 28939740; -.
DR VEuPathDB; FungiDB:T551_01222; -.
DR eggNOG; KOG1166; Eukaryota.
DR OrthoDB; 5479089at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR CDD; cd13981; STKc_Bub1_BubR1; 1.
DR Gene3D; 1.25.40.430; -; 1.
DR Gene3D; 6.10.20.170; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR015661; Bub1/Mad3.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR013212; Mad3/Bub1_I.
DR InterPro; IPR012572; Mad3/Bub1_II.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR14030:SF4; BUB1 KINASE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR14030; MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1; 1.
DR Pfam; PF08311; Mad3_BUB1_I; 1.
DR Pfam; PF08171; Mad3_BUB1_II; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00777; Mad3_BUB1_I; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51489; BUB1_N; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000053447}.
FT DOMAIN 49..209
FT /note="BUB1 N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51489"
FT DOMAIN 652..946
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 420..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 685
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 971 AA; 112817 MW; BD4C715EEE895050 CRC64;
MISFKESIED QKENIEPLRQ GRSVKSLAKA FSEDPCSLKI KNDQERRVFE SEIENLDDHD
DPLDVWIKYI KWTNETYPHG QSAESGLVSL LERCIRCFVN VSYYKEDPRY LKVWIQYMKY
IDDPRELFCF LAYNNIGQSL STFYEEYANF LEENGRKFQA NEIYQLGIER KARPFDRLQR
RYNEFLKRSV ENPSINGPSS PALAPIRSAL STKFLSSLND SGNLVQLNNT KKPSGMSRIN
VYVDSENDER FTKSFKTSKW DNIGTIQERR KENYQEAKQW VGEKLPMKKQ NQQFLFTEKF
TVFRDEENKT FKESLNLFEN PPMPKKEEKI VVNLEAIYCK NGEEFSLDEL KAKAMGLLGK
TWEDNAADSA MVPLCFESKT VLKDSSQAFD LSKKQASPTI NTKAALADIF DIFNQPLKCE
QSDSSSDENN NEIGYEDNSV QKHMENVSQS QDLLDDEFHP NSFNEENKDI NYKDQSESIK
TLRENDKNET IQTYNSFTTP SRENVSSFPL DKHSSSINIT TPIVEDTEQL LLLSHLKPEK
KEKMQFNEES DLISTPYLNL EKKKPTHSTS FKHQSLSNCY VIKEPICNPF EDNIQKTILS
NLNPSNFYGG FYNFSDKIYG KLDLERFNKP SFKKSSHNNQ DLLVKLTENT SYLIKKKLGE
GAFAFIYLAE TKNSSNSTPQ LRAIKIERSS IPWEFYIIRQ VKHRLNLHRA LESIIDVYEM
YIYRDVGFLI MRYRDQGTIL DLVNMFKAET GNGVDEVLAI FFTIELLRTL EQLHNKHILH
GDLKPDNCLV RFDPVETEWL SKYQKDGSGG WASKGIVIID FGRGIDLKMF SPHVQFVVDT
QTDEQDCAEM REARPWTYQI DYHGLATIIH TLLFGKHIET IPEKTLGLGA VRKKYRLASG
FKRYWQQDLW KKLFDLLLNP IANAGEKGLP ITENLKQVRE EMEIWLVENC EKGIGLKGII
WKIETLLQER K
//
