ID A0A0W4ZTP2_PNEJ7 Unreviewed; 656 AA.
AC A0A0W4ZTP2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0000259|PROSITE:PS50021};
GN ORFNames=T551_00973 {ECO:0000313|EMBL:KTW31712.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW31712.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SIMILARITY: Belongs to the alpha-actinin family.
CC {ECO:0000256|ARBA:ARBA00010255}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW31712.1}.
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DR EMBL; LFWA01000004; KTW31712.1; -; Genomic_DNA.
DR RefSeq; XP_018230404.1; XM_018373236.1.
DR AlphaFoldDB; A0A0W4ZTP2; -.
DR STRING; 1408657.A0A0W4ZTP2; -.
DR GeneID; 28939491; -.
DR VEuPathDB; FungiDB:T551_00973; -.
DR eggNOG; KOG0035; Eukaryota.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd21215; CH_SpAIN1-like_rpt1; 1.
DR CDD; cd21291; CH_SpAIN1-like_rpt2; 1.
DR Gene3D; 1.20.58.60; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR SMART; SM00033; CH; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 2.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..116
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 125..231
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
SQ SEQUENCE 656 AA; 75486 MW; 005CB15E22C28E8E CRC64;
MSHLDHSWQE IQHKTFTKWL NTRLSSLDLT PAVSLKTDLS DGIRLICLLE TIGNENLGKY
NKNPRLRVQK AENVNIALEY IKSRGIPLTN IGAEDIIDGN LKLILGLLWT LILRFTIADI
NEEGYTAKEG LLLWCQRQTS GYANVNICDF TTSWTDGLSF CALIHKHRPD LLNFDELDIK
DCRKNITLAF EVASKYIGIP QLLDVEDICD VSKPDERSIM TYIAQYFHAF STLDKVETAG
RRVEKFAKTM QSVSIMQSDY ETKMKQLIDS INKIQTLWGI STFDDSYADA KLQSLEFNDY
KKTLKRDWVK EKLFLESLMH DIQTKLKSYC LKNYIPPKGL ELNDLDITWK GLIKAEVKKS
RQINEKIRDI KENLRRSFAE KANNFSLMLS TISIEISGLK GDLEEQLEQV TLLKEHIKPL
RDELQQLKHL DENCKEAKIE ENDYTNFSYD DLEYELDLAS DSVHKKLQFI ECQILTRQKT
NLTPAQMKEF DAVFKHFDRY GIGALQGDVF TAALAALGLA YDEQEMEDII AKASSDTGVV
TYSQFIDFLV DEMEDHNSPD QVLLAFRDVA DGKVSKQIIL INCLNIFEPY VTELDLRQSL
IPSTEVEYLI SQMPELQENE TEVDEEDHGY PIFDYCSYME SLLDLNDTII KNKNTC
//
