ID A0A0W4ZTS7_PNEJ7 Unreviewed; 784 AA.
AC A0A0W4ZTS7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=T551_01049 {ECO:0000313|EMBL:KTW31788.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW31788.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW31788.1}.
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DR EMBL; LFWA01000004; KTW31788.1; -; Genomic_DNA.
DR RefSeq; XP_018230480.1; XM_018373312.1.
DR AlphaFoldDB; A0A0W4ZTS7; -.
DR STRING; 1408657.A0A0W4ZTS7; -.
DR GeneID; 28939567; -.
DR VEuPathDB; FungiDB:T551_01049; -.
DR eggNOG; KOG1131; Eukaryota.
DR OrthoDB; 124793at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KTW31788.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447}.
FT DOMAIN 7..289
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 748..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 255..297
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 748..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 90850 MW; 26E49A3D9639B8A3 CRC64;
MKFFIDDLPV LFPYPRIYPE QYAYMCHLKK TLDAGGHCVL EMPSGTGKTV SLLSLIISYQ
KFYSEHRKLV YCSRTMSEIE KILVELKNLI EFRKKISEEN SKFRALGLTS RKNLCLHPSI
KHEKKGNIVD ARCRGLTASF VREKKKAGEK VNLCLYYENL NFLDFCDLIP YGVFTFTDLI
EYGEKNQQCP YFIARRMIPF CNVVVYSYHY LLDPKISEFI SRELSKDCIV VFDEAHNIDN
VCIESLSVDI TEDSLKRASH SINSLETKIA NMKKNNAEKL QMEYRKLVEG LREIEKIKEN
DIFITNSILS DDLLKEAIPG NIRKAEHFVA FLKRFVEYMK TRMKVLHVIA ETPLSFLQHL
KELTYIESKP LRFCAERLNS LIRTLELPDI EDYQYLQEIT DFATLVSTYE KGFIIILEPF
ETDTATVPNP VFHFTCLDAS IAIKPIFAKF KSVIITSGTI SPLDMYPKIL QFNAVIQESY
NISLARNSFL PMIITRGSNQ VAISSKFEVR DDPSVVRNYG DILLEFSKIT PDGLVAFFPS
YIYMESIISQ WQNMGILDEI WKYKLILVET PDSQETVLAL KTYRTACDNG RGAILLCVAR
GKISEGIDFD HHYGRTVIMF GIPYQYTKSR ILKARLEFLR DMYHIKENDF LTFDAMRHAA
QCLGRVLRGK DDYGIMVLAD RRFSRTDKRN KLPKWIQQYI TSGTSNLSTD MSIAFAEKFL
KAMAQPFNIK DQEGISWWDI EKLHEYQKKE KQTESKNNED LIDANENEYD VSDEILEISD
DIKS
//
