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Database: UniProt
Entry: A0A0W4ZVS6_PNEJ7
LinkDB: A0A0W4ZVS6_PNEJ7
Original site: A0A0W4ZVS6_PNEJ7 
ID   A0A0W4ZVS6_PNEJ7        Unreviewed;       958 AA.
AC   A0A0W4ZVS6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000256|HAMAP-Rule:MF_03000};
DE            Short=eIF3a {ECO:0000256|HAMAP-Rule:MF_03000};
DE   AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
DE            Short=eIF3 p110 {ECO:0000256|HAMAP-Rule:MF_03000};
DE   AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
GN   Name=TIF32 {ECO:0000256|HAMAP-Rule:MF_03000};
GN   ORFNames=T551_00556 {ECO:0000313|EMBL:KTW32466.1};
OS   Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX   NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW32466.1, ECO:0000313|Proteomes:UP000053447};
RN   [1] {ECO:0000313|Proteomes:UP000053447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX   PubMed=26899007; DOI=10.1038/ncomms10740;
RA   Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA   Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA   Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA   Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA   Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA   Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA   Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT   "Genome analysis of three Pneumocystis species reveals adaptation
RT   mechanisms to life exclusively in mammalian hosts.";
RL   Nat. Commun. 7:10740-10740(2016).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000256|HAMAP-Rule:MF_03000}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03000}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000256|HAMAP-
CC       Rule:MF_03000}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KTW32466.1}.
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DR   EMBL; LFWA01000002; KTW32466.1; -; Genomic_DNA.
DR   RefSeq; XP_018231158.1; XM_018372822.1.
DR   AlphaFoldDB; A0A0W4ZVS6; -.
DR   STRING; 1408657.A0A0W4ZVS6; -.
DR   GeneID; 28939077; -.
DR   VEuPathDB; FungiDB:T551_00556; -.
DR   eggNOG; KOG2072; Eukaryota.
DR   OrthoDB; 10990at2759; -.
DR   Proteomes; UP000053447; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.860; -; 2.
DR   Gene3D; 4.10.860.10; UVR domain; 1.
DR   HAMAP; MF_03000; eIF3a; 1.
DR   InterPro; IPR027512; EIF3A.
DR   InterPro; IPR000717; PCI_dom.
DR   PANTHER; PTHR14005:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A; 1.
DR   PANTHER; PTHR14005; EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT; 1.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|HAMAP-Rule:MF_03000};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_03000};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03000};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_03000}.
FT   DOMAIN          317..500
FT                   /note="PCI"
FT                   /evidence="ECO:0000259|PROSITE:PS50250"
FT   REGION          835..958
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          585..638
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT   COILED          670..697
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT   COMPBIAS        835..918
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        919..943
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   958 AA;  111653 MW;  D6C2CC368BD6C31C CRC64;
     MLIPQSKPEN VLRRAEELIA VGQSAAALQS LHELILSKCS RNTSVSSLKP IMLRFVALCV
     DLRKGKMAKE ALYQYKNIAQ NTSVGTIEVV LKKFIDLVEE KVSEAQVHAE KLVLDAIDDL
     EASETPENII LSTVSGDQSK DRTDRAVVTP WLKFLWETYR TVLEILKNNA RLEQAYQSTV
     NQAFDFCLKY SRKTEFRRLC DILRTHLQNA TKYSGQQHSI NFNDPETLQR HLDTRFSQLN
     AAVELELWQE AFRSVEDINN LLALSKRQPK LFVMANYYEK LGKIFAVSEN YLFHAVIWNK
     YYGLISSQNK GADDKELERV ASLVLLSALA IPVISTTRSK GSIMEIDDTK IRNTKLAALL
     SLSKLPTRNS LLKEALGKNI LVYVRKEIKE LCNILEVEFH PLSICQKVEP LIKIISQDPD
     MIQYIKPLQH VILTRLFQQL SQVYETIKLD FILSLLNFSE PFHIDSIYIE KFIMNASKKG
     ELSIRIDHSS NSLIFETNIF ASHHTIADSN VRLQSTPSEL IRSQLSRIGK CLLTTVCIID
     KSFLHELEDQ KNIANEHTAN GIEKEQKDTL ARRAIIEHRK EVAENMMIYK EKEAATKRAQ
     KLQQEQEAEQ RRVAEEAKKR EAERIKKETD AIRAEEARKL ADELKAKGAL KVDVDGLEGL
     DTSKLRAIQL EQLEKETRDL NEKLRVTSKR IDHLERAYRK EELPLLKQKA IEQFTSDKIF
     YEKARKLQLE ASRVKHDHMV ALKHRFQRLY PDYVIYRETF LEKCRKEFDQ HCKIANEALE
     KAKEERRMAY RLKKEEEERQ RLEEEERKRK KEEERERIRQ EELRLKAIEE ENRARKEEEL
     RKLDQMAEKQ KQKELEVERK LQRKKEELKS LDHNYDRWTK KDRLPPSDPS GEEKWRPGKG
     SWRLRVSERQ ELTDPHSSPN ETKPDPQSKP TSTRPSTTDP PSTGIYKPPA ARKENSRW
//
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