ID A0A0W4ZWQ5_PNEJ7 Unreviewed; 1862 AA.
AC A0A0W4ZWQ5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=TATA-binding protein-associated factor MOT1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=T551_00293 {ECO:0000313|EMBL:KTW32808.1};
OS Pneumocystis jirovecii (strain RU7) (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1408657 {ECO:0000313|EMBL:KTW32808.1, ECO:0000313|Proteomes:UP000053447};
RN [1] {ECO:0000313|Proteomes:UP000053447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RU7 {ECO:0000313|Proteomes:UP000053447};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTW32808.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFWA01000001; KTW32808.1; -; Genomic_DNA.
DR RefSeq; XP_018231500.1; XM_018372560.1.
DR STRING; 1408657.A0A0W4ZWQ5; -.
DR GeneID; 28938815; -.
DR VEuPathDB; FungiDB:T551_00293; -.
DR eggNOG; KOG0392; Eukaryota.
DR OrthoDB; 180798at2759; -.
DR Proteomes; UP000053447; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR CDD; cd17999; DEXHc_Mot1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR044972; Mot1.
DR InterPro; IPR044078; Mot1_ATP-bd.
DR InterPro; IPR022707; Mot1_central_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR36498; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR PANTHER; PTHR36498:SF1; TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172; 1.
DR Pfam; PF12054; DUF3535; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1293..1465
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1633..1791
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1862 AA; 212016 MW; C19970C69D4DCC49 CRC64;
MGVKAGGTRM ERLVLLLDTG STQIIRQTAA QQLAAIQKDH PHELYNILEK VIPYIRSKSW
ETRMAAVLAL SSVIKQVPFW DPDIESIKHE EEESKSFFEK DENISVLKNN PDDIFNFETF
DISFVIKNGQ KLLGSDGKEY DFDSCDIFSE ENLAFQKKSF LSRLGFGEYI DENIITVSDF
TPPANDVVLK QPDDNFASSL MNNTTLSARQ RNAMKRKAKN SAKNTRMNKL FFFIFSIFKL
TIYRMCITST PVSIKNDVPE DSIFSVMSSV KQEDSPESAS SNLQSQTSCI VEHKPSSIKN
SAENLEWPFK KISELLKLDL FHPCWEIRHG AAMGLREIIK IHGKGAGRII GLSKVENNKR
NKIWLEDVAC KLTCIFALDH FGDYISDQVV APIRESVSQT LGALLVHVDS ESVQEVYRIL
YRLVFQQDMN IESRVWEIVH GGMLGLKYLV AVRRDVVFES NEMFNGIIQA VFYGLKNYDD
DVRSVSAAIL SPIASEFVEN RLDAVNDLMN TLWVCLSDLR DDLSTSTVNI MDLLSKLCSS
PKVIDVMKNN AVLDESHSFS FLVPKLFPFL RHTITDVRKA VIKALQKFSN FENDEFKSWI
DGKALRLIFQ NMLVEQNTEI LNSTLDLWNM VVSSIKSDSS LRFYTEYSSH LLPSIELLMT
PIGTPRHPYP MKVPFLDPFG NLNILTSPVE DTINSNTKLS KKQRNKKQDH YVFHNIDKPM
IQGDIDLLGT EVIFESRVTS AKALGFLIAR FPEDKIDEII IYLLKYFLSP FSTPRFLTAI
VFQSFCTNIG DKPSFLTFVQ KHFIDILNGQ LPGMFANLVP YMKILRSQCY ALCNTFIENG
NLEASDIPHI PMVVQGEINA GSDAFSLKDA ERIVDDDFNR LQNMILPIYK AHAYKNLVEA
QKNVKNAIKV AKNAKFLSDV QIMAAVACTL VSTKELPKKL NPIIRAIMDS IKNEESLILQ
THSAKSLTDL IDLCAFSHPG AIDKLINNLC TFLCLDTSEI PEFYCNKTLQ KCILSLKKDQ
EDQCSKDISY EQNSKEIHIK KNGAKLVLIN IAKTFGKNLF EKIPRLYACI FKSIEHVFKE
DSCFKNVEQN PALGQNIIDG LSILRVLVSH FNESLYPLVI EHFGIILKAL ECEFSVVRYA
AAKCLATICS VITVEAMNEV IFHVLPLLKD ADNVIRRQGA VELIYHLVQV MGENMLPYVV
FFIIPILGRM NDSDNDIRVF STTTFAALVK LVPLESGIPD PPGISDVLLK NRDSERKFIS
QILDGSKFES FSIPACIKAN LRKYQQEGVN WLAFLNRYQL HGILCDDMGL GKTLQSICII
ASDHFSKSQE HESEFKEFQP IPSLIICPPT LSRHWQHEFS TYAPFMKTLI YGGSPSERIK
LRDSFEEYDV VITSYDICRN DSEEFSKRNW NYCVLDEGHI IKNAKAKLTK AIKLIKANYR
LILSGTPIQN NILELWSLFD FLMPGFLGTQ KSFHERFVKP ITASRDSKVS SREQEAGALA
LEALHKQVLP FLLRRLKEDV LDDLPPKIIQ DYYCDLSPIQ KQLYEDFAKT QISEVIKRFK
GEKIEKKSHI FQALQYMRKL CNSPALVLNK KHPQYEKINI ELQKQNSNIY DIEHSPKLMA
LRNLLLDCGI CLNDDTLGIQ ANQHRALIFC QLKDMLDMIE NQVFKKLLPN VLYLRLDGDT
DAKQRYEIAH KFNSDFSIDV LLLTTHVGGL GLNLTGADTV IFVEHDWNPM KDLQAMDRAH
RIGQKNVVNV YRLVTKGTLE EKIMSLQRFK LNIASSIINQ QNFGLSTMDT SQILDLFSTI
QDEQSSDVQN SSKMDILDSE GNLLQKNHKN VLENLDNLWD SLQYEESYDL DEFISSLPSI
DK
//
