ID A0A0W7VPS5_9HYPO Unreviewed; 856 AA.
AC A0A0W7VPS5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Coatomer subunit beta' {ECO:0000256|PIRNR:PIRNR005567};
GN ORFNames=TGAM01_v207834 {ECO:0000313|EMBL:PON23307.1}, TGAMA5MH_05114
GN {ECO:0000313|EMBL:PNP43179.1};
OS Trichoderma gamsii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=398673 {ECO:0000313|EMBL:PNP43179.1, ECO:0000313|Proteomes:UP000236546};
RN [1] {ECO:0000313|EMBL:PON23307.1, ECO:0000313|Proteomes:UP000054821}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6085 {ECO:0000313|EMBL:PON23307.1,
RC ECO:0000313|Proteomes:UP000054821};
RX PubMed=26893428;
RA Baroncelli R., Zapparata A., Piaggeschi G., Sarrocco S., Vannacci G.;
RT "Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising
RT Biocontrol Agent of Fusarium Head Blight on Wheat.";
RL Genome Announc. 4:e01747-15(2016).
RN [2] {ECO:0000313|EMBL:PNP43179.1, ECO:0000313|Proteomes:UP000236546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A5MH {ECO:0000313|EMBL:PNP43179.1,
RC ECO:0000313|Proteomes:UP000236546};
RA Gardiner D., Kazan K., Vos C., Harvey P.;
RT "Genomes of Trichoderma spp. with biocontrol activity.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PON23307.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=T6085 {ECO:0000313|EMBL:PON23307.1};
RA Baroncelli R.;
RT "Trichoderma gamsii strain T6085, whole genome shotgun sequencing
RT project.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005567}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005567}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPI-coated vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004347, ECO:0000256|PIRNR:PIRNR005567};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004347,
CC ECO:0000256|PIRNR:PIRNR005567}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004347, ECO:0000256|PIRNR:PIRNR005567}. Golgi
CC apparatus membrane {ECO:0000256|PIRNR:PIRNR005567}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005567}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005567}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Note=The coatomer is cytoplasmic or
CC polymerized on the cytoplasmic side of the Golgi, as well as on the
CC vesicles/buds originating from it. {ECO:0000256|PIRNR:PIRNR005567}.
CC -!- SIMILARITY: Belongs to the WD repeat COPB2 family.
CC {ECO:0000256|ARBA:ARBA00010844, ECO:0000256|PIRNR:PIRNR005567}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PNP43179.1}.
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DR EMBL; MTYH01000049; PNP43179.1; -; Genomic_DNA.
DR EMBL; JPDN02000030; PON23307.1; -; Genomic_DNA.
DR RefSeq; XP_018661473.1; XM_018805302.1.
DR AlphaFoldDB; A0A0W7VPS5; -.
DR STRING; 398673.A0A0W7VPS5; -.
DR GeneID; 29985385; -.
DR OrthoDB; 20819at2759; -.
DR Proteomes; UP000054821; Unassembled WGS sequence.
DR Proteomes; UP000236546; Unassembled WGS sequence.
DR GO; GO:0030663; C:COPI-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR CDD; cd22947; Coatomer_WDAD_beta-like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006692; Coatomer_WD-assoc_reg.
DR InterPro; IPR016453; COPB2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19876; COATOMER; 1.
DR PANTHER; PTHR19876:SF2; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF04053; Coatomer_WDAD; 1.
DR Pfam; PF00400; WD40; 5.
DR PIRSF; PIRSF005567; Coatomer_beta'_subunit; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR005567};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005567};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005567};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005567};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005567};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005567};
KW Reference proteome {ECO:0000313|Proteomes:UP000054821};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005567};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 9..50
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 93..125
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 136..178
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 180..223
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 224..265
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 319..762
FT /note="Coatomer WD associated region"
FT /evidence="ECO:0000259|Pfam:PF04053"
FT REGION 809..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..856
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 95402 MW; 0209B47E5FC152A3 CRC64;
MRLDVKRQLY ARSERVKGID FHPQEPWILT TLYSGHVNIW SYETQQIVKS FELTDVPVRA
GRFVARKNWI VCGSDDFQLR VYNYNTSEKI TSFEAHPDYI RAICVHPTLP FVLTASDDMS
IKLWDWDKGW KCVQVFEGHS HYVMGLAINP KDTNTFASAC LDRTVKIWSL GSGTANFTLE
AHETKGVNHV DYYPHSDKPY LLTTSDDRTV KIWDYTTKSL IATLEGHTNN VSFACYHPEL
PVIISGSEDG TIKLWHANTY RLEQSLSYSL ERAWCASYQK GKQGVAVGYD DGAVVIKLGR
EEPAVSMDPS GKLIWAKQNE VVSSIIKGDA SIKDNEPITL PTKDLGTCEV YPQTLIHSPN
GRFVAVCGDG EYIIYTALAW RNKAFGSAMD FVWASKENSN DFAIRESPMS VKVFKNFVEK
SGGLDVGFQA DGLTGGVLLG VTGQGGVSFF DWNTGGLVRR IEVEPKQVYW SESGELVAIA
CEDTFYVLRF SRENYVEAVQ SGEVEEDGVE SAFEVITDVN ESIRTGEWVG DCFIYTNSTN
RLNYLVGDQT YTISHFDKPM YLLGYIQRDS RIYLADKDVG VTSFALSQPV LEYQTLVLRE
DMETAAELLP TIPADQLNKV ARFLEGQGHK DLALEVATDP EHKFELALAL NQLTIALDLA
RQADVEHKWK TVGDAALTAW DVNLAAECFT HGKDLGSLLL VYSSTGDHEG LAKLVAQAEE
ANAHNVAFSA AWLVGDIDRC VDILTKTGRA VEATLFAQTY KPSLAATAAK SWKESLEKNK
KGRVAKLIGV PDDDAELFPE WDEWLKLESE GGVAADVDMA TPNSKSEEEG EAEAQEEAEE
EEQDEEMEEA KEEQEA
//
