ID A0A0W7WTT6_9ACTN Unreviewed; 617 AA.
AC A0A0W7WTT6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Peptidase {ECO:0000313|EMBL:KUF14005.1};
GN ORFNames=AT728_01850 {ECO:0000313|EMBL:KUF14005.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF14005.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF14005.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF14005.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF14005.1}.
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DR EMBL; LOCL01000062; KUF14005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W7WTT6; -.
DR STRING; 1765722.AT728_01850; -.
DR OrthoDB; 9781963at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd06164; S2P-M50_SpoIVFB_CBS; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR39188; MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B; 1.
DR PANTHER; PTHR39188:SF3; ZINC METALLOPROTEASE SLR1821-RELATED; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF02163; Peptidase_M50; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 248..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 288..361
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
FT DOMAIN 375..428
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
FT DOMAIN 495..541
FT /note="CBS"
FT /evidence="ECO:0000259|Pfam:PF00571"
FT REGION 1..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 64060 MW; E50CC08B292F4228 CRC64;
MDESGGSGRP QSDEYAPAEA EDATTRARET PAEHGAGPAR TQDDAPRGRD DASRPEDDAP
RTEEGPAGAE GSADRAEDPS PRVDGTAART AEATPRSEGG DARAADVPGG TGGESAHAGE
AAPPSGTSPR PGAPQGTGIP AGTGAAAPAR PGATVSVRKG PELGGGATED GSKATEGDEA
TAQPHTDRPH AEEPRTEQPH AERPRTEQPP TAPAERAHAH HQPPSGVPPK EEPKNPGGGL
LMGRPFGVPV YVAPSWFLVA ALITWVFGGQ LDRVLPELGN ARYLVSLFFA VAFYASVLVH
ELAHTVAALR FKLPVRRIQL QFFGGVSEIE KESETPGREF VLAFVGPLLS LVLAGVFYAG
MRAVEPGTVP GVLLAGLMIS NLIVAAFNLL PGLPLDGGRM LRAVVWKITG RPMSGTVAAA
WVGRALAISV LVGLPILNQS GALGGETQDI GGMDTVTDAL LAAILAAIIW TGAGNSLRMA
RLREHLPELR ARALTRRAVP VETDTPLSEA LRRANAAGAR ALVVVDADGD PLSVVREAAI
VGVPEHRRPW VTVSGLAQDI TEGMRIPADV AGEDLLDRLR TTPASEYLVV EGSGEIYGVL
SAADVERAFV KAMARPS
//
