ID A0A0W7X394_9ACTN Unreviewed; 503 AA.
AC A0A0W7X394;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN ORFNames=AT728_15890 {ECO:0000313|EMBL:KUF17300.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF17300.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF17300.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF17300.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF17300.1}.
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DR EMBL; LOCL01000034; KUF17300.1; -; Genomic_DNA.
DR RefSeq; WP_058848563.1; NZ_LOCL01000034.1.
DR AlphaFoldDB; A0A0W7X394; -.
DR STRING; 1765722.AT728_15890; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804}.
FT DOMAIN 19..481
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 503 AA; 52438 MW; 602E15C777DA5713 CRC64;
MTNTTKTVDH WIGGKSVEGA SGTYGPVTDP ATGAVTTRVA FASPAEVDAA VAAAKGAFTA
WGQSSLAQRT SILFKFRALL DAHRDEIAEL ITAEHGKVHS DALGEVARGL EVVDLACGIS
VQLKGELSTQ VASRVDVSSI RQPLGVVAGI TPFNFPAMVP MWMFPLAIAC GNTFVLKPSE
KDPSASMRVA ELLAEAGLPD GVFNVVHGDK VAVDRLLAHP DVAAVSFVGS TPIARHIHTT
ASANGKRVQA LGGAKNHMLV LPDADLDAAA DAAVSAAYGS AGERCMAISA VVAVGAVGDT
LVAKIKERAE KIKIGPGDDP ASEMGPLITA AHRDKVASYV EGAAAQGSEV VLDGTGFTVE
GHEDGHWIGL SLLDRVPVTA DAYKDEIFGP VLCVLRVDTY EEGLALINSS PFGNGTAIFT
RDGGAARRFQ LEVEAGMVGV NVPIPVPVGY HSFGGWKDSL FGDHHIYGND GTHFYTRGKV
VTTRWPDPSD APAGVDLGFP RNH
//
