ID A0A0W7X3U0_9ACTN Unreviewed; 553 AA.
AC A0A0W7X3U0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=AT728_08605 {ECO:0000313|EMBL:KUF17487.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF17487.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF17487.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF17487.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF17487.1}.
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DR EMBL; LOCL01000033; KUF17487.1; -; Genomic_DNA.
DR RefSeq; WP_058847953.1; NZ_LOCL01000033.1.
DR AlphaFoldDB; A0A0W7X3U0; -.
DR STRING; 1765722.AT728_08605; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KUF17487.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KUF17487.1}.
FT DOMAIN 16..225
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 284..514
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
FT REGION 534..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 57442 MW; E4567149EDBE5B96 CRC64;
MSPTSNLPGL PAHGHVTFLG AGPGDPGLLT LRAVEALARA DVLIAEPDVL DVVRVHARGG
VDTPLPQAAD GTSASVDGPS ASVAANLVME GARGGRRVVR AVSGDPGLDA YAAGEMLACA
AEGIPFEVVP GIAAAVGVPA YAGVPLRDAQ GTDVRFVDAR TASERCWGEV GASDGTVVVS
TSLDSVAAAA GELVSAGRKP DTPMTVTIAG TTTRQRTWTA TLGTIAQVLK QAKVLPSPDG
GQPVIAVVGE RSAAAQRDQL SWFESKPLFG WRVLVPRTKE QAASLSDQLR SYGAVPHEVP
TIAVEPPRTP QQMERAVKGL VTGRYEWIAF TSVNAVKAVR EKFEEYGLDA RAFAGIKVAA
VGEQTAAALV AFGVKPDLVP SGEQSAAGLL EDWPPYDPVF DPIDRVFLPR ADIATETLVA
GLIDLGWEVD DVTAYRTVRA SPPPAETREA IKGGGFDAVL FTSSSTVRNL VGIAGKPHNV
TVIACIGPAT AKTAEEHGLR VDVMAPEPSV HRLAEALAQF GAARRAAAVE AGEVVTRPSE
RRPGARRRRA AAP
//
