ID A0A0W7X4C8_9ACTN Unreviewed; 339 AA.
AC A0A0W7X4C8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=NADP-dependent oxidoreductase {ECO:0000313|EMBL:KUF17785.1};
GN ORFNames=AT728_10395 {ECO:0000313|EMBL:KUF17785.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF17785.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF17785.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF17785.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF17785.1}.
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DR EMBL; LOCL01000033; KUF17785.1; -; Genomic_DNA.
DR RefSeq; WP_058848222.1; NZ_LOCL01000033.1.
DR AlphaFoldDB; A0A0W7X4C8; -.
DR STRING; 1765722.AT728_10395; -.
DR OrthoDB; 9805663at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05288; PGDH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR041694; ADH_N_2.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR045010; MDR_fam.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR Pfam; PF16884; ADH_N_2; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804}.
FT DOMAIN 17..332
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 339 AA; 34881 MW; E1B129DD3EB52B7C CRC64;
MPSSREYRLA ARPVGFPSPS DFELVTTEVP DTVTDGRVLV RNTWMSVDPY MRGRMDDVPS
YIAPFELGAP LEGSAVGEVV ASGSPDVPVG ASVSHFAGWR EYAVLDAADV TVIDTTAAPA
SAYMGPLGAT GLTAYATLKR IAPVREGDVV FVSAAAGAVG SVAGQVARAL GASRVIGSAG
GPGKTKKLLD TFGYDAALDY RQGALDEQLA QAAPDGIDVY FDNVGGGHLQ AGIGAIRRNG
RIALVGGLGE YNATAPVPGP SNLLQAAKQE ATLRGMLVTS HLDLFPEWIA TASAMIADGT
LRTEQTVVEG ITAAPDALLG VLRGANTGKM LVKLVDGAK
//
