ID A0A0W7X8T2_9ACTN Unreviewed; 2475 AA.
AC A0A0W7X8T2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KUF19304.1};
GN ORFNames=AT728_30235 {ECO:0000313|EMBL:KUF19304.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF19304.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF19304.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF19304.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF19304.1}.
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DR EMBL; LOCL01000027; KUF19304.1; -; Genomic_DNA.
DR STRING; 1765722.AT728_30235; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804}.
FT DOMAIN 1029..1103
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2101..2176
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 469..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2475 AA; 266080 MW; D79B7BF08666343B CRC64;
MSRPTRLPLT AYQRDIWAAS ALDESHPQFN CVVHERLTGR IDIPALRASL ARAVRRHDAF
SLSFDADDDV PYQWQDPEVG AAPDNALVTL ADLSDEADPR AACAQWVERA LARPFPLRRS
RMFDIRLLRE GPGAVHLVVR AHHIVTDGYG IFHFTEQVFE DYARVKAGAE PLAGTAPSYA
DFVAEEARYT ASPQFRQDQD FHRRALGDVE PALFSRANGP TADGPATGRY SFTVDSSLVR
RLREQERLVF PVVAAAFATY LGRVHRAREV VLGIPMLNRR SGEELATVGH FANILPLRLP
TDGSVTMRQL GAAVERGSEE LRRHERLALG DVLRALPRGS GGAPRLFDVT LSYLPMPPGP
TVAGLTRETR GSAPAHAQDA VAVHVLHTRG TDDVRITLVH ARDVCDEDFP VRALADHVTA
LIRGAVEEPD RPIGSLPMLG AAERRKLEAA ARGPRVSHPE LRTLHSLFEE QAARTPDRRA
VLAGTTSGGP GDGRSGEPGA DPSGTDPSGA DPSGADPSGE PGGGPSGVGS LTFGALDAAA
DRVAHALRAV GVGADDRVAV LLERGPLTPV AVLGVLKAGA AYVPVDPGHP PARIAFVLRD
SRAEAVLVGP GSPVVDGMGP AEVLRVDELL RSEEAPHAPA AVPPESSATS RDLAYVIYTS
GSTGTPKGVM VEHRSVVNRL AWMQRAYPIG ADDVILHKTP IAFDVSVWEL FWWAVEGAAV
APAPVGAEKD PAALARTVAG HGVTVAHFVP SMLGPFLDLL EESPQARAEV RSLRYVFCSG
EALPPAHVDR FNRIFGADGA ERPAPKLVNL YGPTEATVDV SWYDCPADPG RPVRRVPIGR
PIDNTDLYVL GAHEDEPQPF GVPGELCVAG VGVARGYLDR PELTREKFTA RPSVPGGRLY
RTGDLARVLA DGTIEYLGRI DGQVKIRGNR IELGEVEHHL ATAPGVRGAV VDSTTSALGT
RLVGYYLADE PVDDAALRAH LARDLPDFMI PAYLVRVDHI PLTPNGKTDR RALPAPDIAH
GASGGPSAPP RDATEATLVS VWSEVLGQRE VGIHDDYYAL GGDSLLTIRI QARAARLGVH
FAPNDLVQHP TVAALAVHCT GGPREPAPDL APFALVPEEI RDSLLRSGNV EDAFPLTRLQ
LGLIYHSEAQ EGSAVYHDVF HYSFRLPWAE DSFRSAFDKL VARHPALRSS LDLGGHAEPL
QVVHRQVTGG LTVVDQRGMP RADADAAVDA YIEQQRHLCY DLSAAPLCHF RVHVRADTVE
LVLGFHHALL DGGSVASLLR ELLDGHLRGL GENTDPAPTD VPPSPAHHVR AERAALESPD
DRRHWKERLD GARGAQLDGF RSAAPVTGPA GFVTHRAALP DGVEHRLRAF SRAHAVPVKS
VLFATHCLTL RLFSGQHDLT TGLLTHGRPE RADGDRTAGL FVNTIPVRMN DTAGTWLAVV
REAHREERRS HPHRRYPLSA IQEDSPRGPV VRTAFNYVNF HILAPVLDHP SVALLSLRTF
EETDFQLLVN AVTDPGDGGL WLRIDGDGRT FTAEQAELVG RAYTAILTRL LDRPEEPADL
GFLATTGPLA APPAVRVAAA PEAPVDVVRL FARQAARTPD AVALVQGTRR WTYRELDRAA
ERIAGRLLGL GAGPGARVGI AMDRAPETVA VILAVARAGA ACVPLDTGYP AERIASMLDQ
ARPVLVVAHR DHAPLVGGPA EVALAEDLLA QDDRETAGAE GAEAPGPDPD STAYILFTSG
STGRPKGVVM PHRSLAALVA WQNRRPSGAV GGTTVSYAPL SFDVSFQETF STLCSGGTLV
LATEAERRDM PALLRLIDRH GVERIFLPYV ALQQFAEAAC ALGPVPRRLR ILVSSGEQLR
VSEEIRRLCA LLPGVVLENQ YGPTETHVVT SFTMSGDPAA FPPLPPVGTP VDGAEVHVLD
AGMRPVPDGV KGEIHLGGSC LADGYTGAPE LTAERFVPHP AGGGRRLYRT GDLGYRLPGG
DIVYAGRADS QVKIRGFRVE PAEVELAVAR LAAPSTGVRE VAVVDRRRGT DSFLAAFLVG
DGTPADLGAL RDRLRAALPE HLVPSHVQWL PGMPLTPSGK RDDAALRRTE LTTASPRTGV
AARDPYERTL VEVFAELLGV PAPGVHDNLF ELGGTSITAM RLVMLVEQRL GVRLPLSALV
AAPTPAAIAE RLRPAAAAPD SRDVLVPFRR DGGRPPVFFV HPLGGNVLCY LTLARHLPAD
QPFYGIQAAG FDPDTEPHRS IPEMAAAYVE AVRRVRPDGP YVIGGWSFGG FVAFEMTRLL
RRAGQEVLPP ILLDTVALSP DAPRNVTDTS LFHFFFWELL WADGGSEIRV EELSREIGSE
EEVFRRAAEI AERNGILPPG DSHDAVRRLY DVFRANYEAL MNESGEVDDQ DLVLLHAQGA
LPEVLKPLHE GAGSLHGDPT NGWRTRTTGA IEVVDVPGDH LQVVEEPYVK YVAEQITRLV
PATPPNTGHG PRGER
//