ID A0A0W7XA96_9ACTN Unreviewed; 745 AA.
AC A0A0W7XA96;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=AT728_04040 {ECO:0000313|EMBL:KUF19554.1};
OS Streptomyces silvensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF19554.1, ECO:0000313|Proteomes:UP000054804};
RN [1] {ECO:0000313|EMBL:KUF19554.1, ECO:0000313|Proteomes:UP000054804}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF19554.1,
RC ECO:0000313|Proteomes:UP000054804};
RA Johnston C.W., Li Y., Magarvey N.A.;
RT "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT novel hormone antagonists.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF19554.1}.
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DR EMBL; LOCL01000026; KUF19554.1; -; Genomic_DNA.
DR RefSeq; WP_058846058.1; NZ_LOCL01000026.1.
DR AlphaFoldDB; A0A0W7XA96; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000054804; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054804};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 674..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..329
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 724..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 77003 MW; 22DDFAF9AD7AF7AD CRC64;
MATFLYKLGR LAFRRRHFVA LIWVALLTLA GVGAASAPTA ASNSFSIPGT EAQRAFDLLE
QRAPEASADG ASARVVFKAP DGAKVTDPDR KAAIEKTVAA LGSGSDQVAA AADPFAAKAV
SKDGTTAYAS VTYKVTSMEL TDDSRDALEK TTDEARADGM TVEVGGDALQ AMPHTGATEI
IGIAVAAVVL VITFGSLVAA GLPLLTALIG VGIGVSSITA LASALDLGST TSTLAMMIGL
AVGIDYALFI VSRYRAELAE GREREDAAGR AVGTAGSAVV FAGLTVVIAL VGLAVVNIPM
LTKMGTAAAG TVAIAVLIAL TMIPALLGYA GRKVKPAGEK SKLLGGRRAA AGAGGGAERP
AKENLGTRWA RFVVRRPVAV LLLGVLGLGA AAVPVAQLEL GLPDDGAQPT STTQRKAYDL
IADNFGPGFN GPLMTVTDLK GVDDPKGEAD AVQKKIAGMD DVLSASPPQF NKAGDTAMIT
VVPSSKPSGT ETEDLVHAIR AEAKDVKADS GADVMVTGST AMNIDVSQKL NDALLPYLAL
VVGLAFLLLI VVFRSILVPL KAALGFLLSV LAALGAVVAV FQWGWLGSLF GVEQTGPIMS
MMPIFMVGVV FGLAMDYEVF LVTRMREAYV HGESPHEAIV TGFKHGARVV SAAAVIMIAV
FAGFIGSSEQ MVKMIGFGLA IAVFFDAFIV RMALVPAVLA LLGRKAWWLP KWLDRTMPNV
DVEGEGLRDT ADQGDSDGKR ELVNA
//
