ID A0A0W7YMP4_9BACI Unreviewed; 681 AA.
AC A0A0W7YMP4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846, ECO:0000256|RuleBase:RU363016};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU363016};
GN Name=recG {ECO:0000256|RuleBase:RU363016};
GN ORFNames=AK833_03985 {ECO:0000313|EMBL:KUF36431.1};
OS Lysinibacillus sp. F5.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1700846 {ECO:0000313|EMBL:KUF36431.1, ECO:0000313|Proteomes:UP000053086};
RN [1] {ECO:0000313|EMBL:KUF36431.1, ECO:0000313|Proteomes:UP000053086}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F5 {ECO:0000313|EMBL:KUF36431.1,
RC ECO:0000313|Proteomes:UP000053086};
RA Chan X.Y., Chan K.G., Hong K.W., Tan A., Chen J.W.;
RT "Draft Genome of marine Lysinibacillus sp. F5.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Critical role in recombination and DNA repair. Helps process
CC Holliday junction intermediates to mature products by catalyzing branch
CC migration. Has a DNA unwinding activity characteristic of a DNA
CC helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-
CC DNA). {ECO:0000256|ARBA:ARBA00024832, ECO:0000256|RuleBase:RU363016}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363016};
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504, ECO:0000256|RuleBase:RU363016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF36431.1}.
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DR EMBL; LKIE01000024; KUF36431.1; -; Genomic_DNA.
DR RefSeq; WP_036124807.1; NZ_LKIE01000024.1.
DR AlphaFoldDB; A0A0W7YMP4; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000053086; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR CDD; cd17992; DEXHc_RecG; 1.
DR CDD; cd04488; RecG_wedge_OBF; 1.
DR CDD; cd18811; SF2_C_RecG; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004609; ATP-dep_DNA_helicase_RecG.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR NCBIfam; TIGR00643; recG; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 2.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363016};
KW DNA damage {ECO:0000256|RuleBase:RU363016};
KW DNA recombination {ECO:0000256|RuleBase:RU363016};
KW DNA repair {ECO:0000256|RuleBase:RU363016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363016};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363016};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363016}.
FT DOMAIN 270..431
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 464..615
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 681 AA; 77434 MW; 070ED0CC0C8F0C25 CRC64;
MTELFSHVNE VKGIGKETAA HLESLGINTV ADLLWTFPHR HEDFRLKDLA QTPHNERVTV
ECKVEREPTI LFLGRNKSRL QVTVLAGRHL VKVVFFNQGY LKQKLVPGSI ITVTGKWDRG
RQVINGTTVT FGPKTDQVDF EPVYSLKGLI PQKRFRKYMR QVLDDFGAEL PEAIPYYLQE
SYKLVPIREG LEGIHFPLDA GHAKQARRRF AYEELLNFQL RIQALRKTRK ESERGTIIQF
DVHKLRAFIA SLPYELTNAQ KRVVNEICKD LKEPHRMNRL LQGDVGSGKT VVAAIGLYAA
VTAGFQGALM APTEILAEQH LENLKEWFQP FDVRVALLSG STKTKERRGI LADLANGDLD
IVIGTHALIQ PDVIFQKLGF VITDEQHRFG VEQRRILRDK GENPDVLFMT ATPIPRTLAI
TAFGEMDVSI IDEMPAGRKQ IETHWMKKEQ LGSVMSKLEL ELAAGRQAYA ICPLIEESDK
LDVQNAVEIY EQLATYFKDR YQVGLMHGRL SADEKDAVMR DFSEGTIQLL VSTTVVEVGV
NVPNATFMIV YDAERFGLAQ LHQLRGRVGR GEHQSYCILL ADPKSDEGKE RMQSMTETND
GFRLAEKDLE LRGPGDFFGR KQSGLPDFKV ADLVHDYRIL ETARKDATEM LETKAFWQDD
DYQYLRKMLE ESGVLQGERF D
//
