ID A0A0W8AXU8_PHYNI Unreviewed; 660 AA.
AC A0A0W8AXU8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=AM587_10008664 {ECO:0000313|EMBL:KUF64320.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF64320.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF64320.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|RuleBase:RU361147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF64320.1}.
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DR EMBL; LNFO01006138; KUF64320.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8AXU8; -.
DR EnsemblProtists; KUF64320; KUF64320; AM587_10008664.
DR OMA; AIKASWP; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943}.
FT DOMAIN 31..87
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 89..480
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 537..615
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 660 AA; 73338 MW; 5AD06FBAC3209C4E CRC64;
MGDSAGVSFN GVYPVPDGFS KTAHVQSMEQ YEAMYKRSLE DPESFWGELG RENLDWFREF
DQAVVGTVNK GDTAWFLNGE TNVSVNCIDR HVKKHPNKTA IIWEADEIGQ GREISYTELL
EETCRIANAM KHAGVRRGDT VAIYMPMIPE VAFVMLACTR IGAVHSVVFA GFSADALRDR
IVDAQTQWVF TSDEGKRGGR TLPLKQIVDH AVNGLDFVRK VFVFKRTHNP EVKMNPKIDV
DMDQELLRHR PYCPAEFMNS EDLMFILYTS GSTGTPKGIA HTTAGYLLYA MXTCKYTFDL
HDDDIFACVA DAGWITGHSY IIYGPLANGV TTLMFESTPM YPDHGRYWDL IQRYKVTKFY
TAPTAIRALM ARGNDKIKEY DLSSLKILGS VGEPINPEAW KWYYEVVGNR QCYIADTYWQ
TETGGHIGVG LPGATPMKPG SCTKPFFGID FVVTDENGNE IKGNDIEGQL CIRKPWPGMA
RTVYGDHNRY LKVYMSSHKG LYFTGDGCRR DKDGYYFITG RIDDVLCTSG HRIGTAEIES
ALVAHNVVAE AAVIGIPHRI KGEGICCFVT LVDGVNGSND VEKELVQQVR AQIGAFATPD
LIVLVPGLPK TRSGKIMRRV LRKISHGEED SLGDVSTLAD PSVVPTLITN TKASLAGKTF
//
