ID A0A0W8C3N1_PHYNI Unreviewed; 931 AA.
AC A0A0W8C3N1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Polycystin Cation Channel (PCC) Family {ECO:0000313|EMBL:KUF78657.1};
GN ORFNames=AM587_10014910 {ECO:0000313|EMBL:KUF78657.1}, AM588_10003663
GN {ECO:0000313|EMBL:KUF92508.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF78657.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|Proteomes:UP000052943, ECO:0000313|Proteomes:UP000054636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Race 0 {ECO:0000313|EMBL:KUF78657.1}, race 0
RC {ECO:0000313|Proteomes:UP000052943}, race 1
RC {ECO:0000313|Proteomes:UP000054636}, and Race 1
RC {ECO:0000313|EMBL:KUF92508.1};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF78657.1}.
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DR EMBL; LNFO01005288; KUF78657.1; -; Genomic_DNA.
DR EMBL; LNFP01000463; KUF92508.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8C3N1; -.
DR STRING; 4790.A0A0W8C3N1; -.
DR EnsemblProtists; KUF78657; KUF78657; AM587_10014910.
DR EnsemblProtists; KUF92508; KUF92508; AM588_10003663.
DR OMA; DYAGMAD; -.
DR OrthoDB; 52189at2759; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR Proteomes; UP000054636; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF20519; Polycystin_dom; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..239
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 334..421
FT /note="Polycystin"
FT /evidence="ECO:0000259|Pfam:PF20519"
FT DOMAIN 444..660
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 931 AA; 103160 MW; 667F27A3934DB073 CRC64;
MLRRHRVGDD SEVEAGQEGN DAKSTEISLA APTSPSSTTP DPHASSATDS APHVQRDDRI
KRIARNPVPF GSLVEAMSYV VFLILFILAT TVVEENTQAF YFANRLKTAL VDQSFTVPTV
STSSTSTSPP VSSSLPTSFT AIRDQAQMWA FLQGPFADVV YGTVDVRNAT TETGSVIATS
NRLLGGVRLR TLRVKAGTCP PLRQIPEYET IVPFCYGKFS SDVEEKKGYG LILNSEDIVA
SISYATARLF FNDLELNDVT KTYTHLQTCY SDCERVCGEE FGVDKFRYIS QCTAQCAVQC
TCIYEEPIGI HLCTDPNPNG EGGAIPTAVH AYNWSSAKVT QAMTVRGYTD VSFPGSGYVV
DLGLNGTLSR ERLVELKTDR YLDLPTRALI VDFTVYNAYL QLFNIVEIVV EFPASGGAFV
QLSDAVLRLF RYSSVSTGRI ILEGFVVFYV MIQWWRMLKE MYRDGVKGFL TASLWNVLTA
LHLVVFAATI AVRLYTIDLA YGTMSGKAAK AVTSASLEEI PNLQGLATVL YVESVVESIN
AALVWIKLLQ YTTVSKRMSL LLRMLGRAAR DLAWFFVCFL VCICAFAQIG LLLFGLDVRG
FSSLGVAIVT LLQAVAGELD YVGMADSHRV AGPVFYILYY LLLLLILVNV FLAILNDAYM
QTITEQEEED EELATAAHDH LMGWDESGDV VDANADISPS EERALQAARR EMEQLRKYPF
SKGFSPAFRL LVADSKRFIA EIRHGNKGVN FTKVDPLIML PKTKNKWPEP SETASRKLTR
HVKRQVASEL LEAEDRMRVS RRVELQQSQI ENLRHTVDED VAARLEALAE SNRLKTRRMQ
DLEKTLGSIE KLCMQLVSDT ACLRVDSDED GEKTRPSSRT ASSRPSRTSS PAIGGKRKSS
GGSKRSLSFA IMTNRQKERK SAGEEIEEIN L
//
