ID A0A0W8CCU4_PHYNI Unreviewed; 317 AA.
AC A0A0W8CCU4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Methylenetetrahydrofolate dehydrogenase {ECO:0000313|EMBL:KUF81869.1};
GN ORFNames=AM587_10011583 {ECO:0000313|EMBL:KUF81869.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF81869.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF81869.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF81869.1}.
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DR EMBL; LNFO01003944; KUF81869.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8CCU4; -.
DR STRING; 4790.A0A0W8CCU4; -.
DR EnsemblProtists; KUF81869; KUF81869; AM587_10011583.
DR OMA; CKVITAE; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052943}.
FT DOMAIN 12..125
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 148..306
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 317 AA; 35385 MW; 52F87E9BCA51F76D CRC64;
MTDTAGVKVN AATIAEPFSL AVRQYIEQDM GGVGPKLVGL LAHGDPAAKK YAEWTGKACA
RDGIRYELRE VPKDELLEAL EKANNDPDVH GILVYYPCFG AFPSFFGGTM DDFLRDSISI
KKDVEGLCQF YRGNLYRNIR YVDDEKMQKC VLPCTPLAIV KILEHLGIYD KTKPAGDHLA
GVNITVINRS DIVGRPLAAM LANDGADVYS ADIDSLYLFR RGKLIPSEET QETACKKSRV
IITGVPVKSY KLPLEWVSEN TVIINVASFK NVDEAELLKI KGVQYVPLVG KVTVAMLERN
LLRLYENFHW KPKKVWQ
//
