ID A0A0W8CNP4_PHYNI Unreviewed; 2742 AA.
AC A0A0W8CNP4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=cGMP-gated cation channel alpha-1 {ECO:0000313|EMBL:KUF85747.1};
GN ORFNames=AM587_10004422 {ECO:0000313|EMBL:KUF85747.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF85747.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF85747.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF85747.1}.
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DR EMBL; LNFO01002421; KUF85747.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8CNP4; -.
DR EnsemblProtists; KUF85747; KUF85747; AM587_10004422.
DR OMA; HRGKTKW; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 4.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 3.
DR Gene3D; 2.60.120.10; Jelly Rolls; 4.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF11; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 3.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SMART; SM00100; cNMP; 3.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 3.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 767..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1315..1334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1354..1377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 985..1085
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1494..1612
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 2464..2578
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 579..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1675..1697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1739..1765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1852..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2678..2712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1852..1884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2742 AA; 311365 MW; BF93ECA3907DD5BE CRC64;
MKVYASSVSG GPTLKGPSVV TQGFRSKPSH LRRPRRWPFG PIETAYEKLP WTTRQTIRSS
ISLCAVLYIF FTVPFRIAFY YDPFNYGTTN TLGWTEELSL FVAMDAVADL MGILEFLRFY
QRQKKVFGPR FASFNVSKTH NLQQSTRLLM RSSSFKIQHR GKTKWTLASI GRHGNTMDDT
ISNRNFVRTQ KLQLILEVVA LLPVEIITYA TGAYNSLHLV RITKLCRLYK LRHCLERFTN
IYSDRTWVQH LSSIGIASLV KNIGLCAGLC HYVACGYMLI AHAQCGVSLE ACDDHVETSW
AVRDGLFGAS VARKYARTLY WASRTMVLLG YDDVTPVSDV ETIYALVVIL MGALFGSSLL
ATFLFIFRFR NARYAAFSTH VDNAREYMRS QNIPRVVRRQ VIAYFSYAWN THHSLDSEEA
LHLMPKHLQS KVISTLKASR IKQVCFLAKE NVEFLNLLAA ALVRCVYSPA DQIIEPKFNA
QMFFVIRGTV MLSSFDGSNS KECQTGDFFA DSCLLFPETF EEKAVAKTFC ELYVLAKSKF
DDAMSEFHRD NEGDVRAGMA ETLEKYTTQL RKTKKLLGAH NRAGSTRRAG DLNNSTTESS
HNRSRNVDWK LPGSAFRIHW DAVRLLSIIF IAFEVPYFSV FISITNEQHL FVEQPEFGLR
YSLAFLIEVL FGADLVLRSR YFAHLDPIVM LPIEDPQLIF AAYKANGFYV DLIAWLPVGV
ILESLATASD QKYSWMFRLL RLLRLRKVPE LLWSICDYCS VSSKAHLVIS LLLGVTFMLH
VVGCVWFEMA WISEIGNTEH AEKSILMELS RPECLKHSTL FDNCSWVTFD CYAHIGDSFP
AENPDSMYQA SFAYMRSVYW AIVTLTAVGY GDIVAYSTGE SFFAAFWIFV GGIINFGVVG
AMSSTISNAM APHHHHMEKL NSLNSVLERM DISEKLSTEI RRFYHHAFTG RKQAYESQLL
SHLPDQLCYE ISSLLHSESV KSVTLFDSAS IEFLKEVTGK FRHRIYQNGD SICLEGDICR
EFFVFLHGSK VNVFFRSRKV PIRALHEGDS YGVMAFLLRR AHPATLTAAS LVHASVMTRD
QFDVIQRKFD DDLKDMKEEA QTLWDEQQKN MRRIVRNLER LKLQPHMMST STLFYQGDTT
VTPTVGGRKE SKVVRDVNAT REVLSSVWKA IVMCGNVYNT IFVIVRICFH SHLHFSSGTN
TAIWAADICC DIFFALDIYL RLYYFGCPDV GLENLIERKE VDKQYRRSST LKWDILASLP
LYTPFASGSL TASLCRLPRL IRCIDIWTYL DDGIILIQQH FASHNVSAYL SPVKLMIILV
LVAHYVGCIF FWISEHECEH VQKCWVDNDH LLHQYHHSLI MLYAKSFYWA ITTLLLVGSR
ESVPRDTAGT LWTGFTCLCC TFIIGHIVGE ISELILELGK EVKHYKSRIA SFDGFAKENE
LPVSLRKRVG FFFKEQFEHT KGTDLHNTIH DLSANLRLKL MLEVYGHSIS LLPISRFLTS
SQVNNLALRL KSEIFIPGDN ILVEGTFGSR LCTLRRGIAA VFWTSSVTSV AILMEGALFG
EVAFFLSGQR RLATVRAATA CEVLFVTKHD WQELWTSTGD MSDIQVQKHA QHAIFNWVHT
RLLRYQRASL RAASKAKRLL SSRHTLHTTM AAASGTSKAR TRLSAVLLNH RESSDVGTST
LGNLSPSSRY GSSKTGDSRR ISIASEMQIL ERKTKYLLAK TDKCAKKYHP AIEALHTHRR
SSSIISGKSL RSSVSHSRSR GNSSGVSGVY RSMIGDSVTP IARNNTVTTL DIRLVQFIID
MNPINKYVRD GLSDEHVRSI EKECWTRFKL LSVAQYGITR LLEELAPSDT LFSQSPGASG
SMDQRSPVKI QPARNGTLHR TRSLRSGENT SRKRSIDELV MAASNRRGSG PEASKKWKAL
AIAAAPRLSA LFSKRNVGGL RDRRLSIEAQ EFHLTRTEQS ARLSRMSRCH SLPQFGREFF
DEIRRGDSTH LSVNSTQPGI DFETLQRCQR PQHSMQLRLF HRYRAWKDGN QATVLPEHHN
SIRRNLNDTI PRTSSLIDRS AAIGSRLHIA SQQALHMAKT ELKATKFIKD VQLMGKFWDL
AMLLVAIYHS LITPFKVCFS PELSELSDAA LRGWSGFEIF MDLLCLFDVC YKLWHSSTAQ
ENGVSSLSSS RQPGIRRALA SNPALRTDIV AMLPLELLLF NSNVRISLPS IEGHGSWWTS
RWILRMNRML LVSHIEPLTE QLFQFLIYDR KVQVNEAVLY FMRGLSSYLT MGHLLACMWY
ITSYVGLQHY GTSWLATSGM LTSIQDVKHS PQRRLSEHVS SFSLETVSLS RKYLRSLLFS
LECISTLFYG DILSMNPMEL VAEIVITLWA IYIYGALVGA QGELLDARAK REAAFEQTLG
ELHHYLVQNE VPKDIKRQVK VYYARLWARR KGEAEYAAVA HVSRSLYEDV VLATLRGFAV
QVAAFRSLDD PFLRALLACL HYVVCSEKEE VFVIGDMDRS MYFIAQGRVA VKMGNSESIR
ERGEFFGELA LLYGISRLET CSAVTVTELY RLDHEPYERL LLEFPEYRAR NKLSWTTMST
SSTRERSIVE EAVRCFNKPG KTRNPGLEGP SSQIPTLLNM ESIAINAERI DAQLPHSYIY
RSAMELLSRL NKVHPLEAKD LYVRSRYGAR RQLKTVLGSA TARPEAEDAV RSFHSSPGTP
RETSIHEHHS DSLEHLEAVV AELSRPTDHQ RTETIKKAFE KA
//
