ID A0A0W8CQJ8_PHYNI Unreviewed; 3044 AA.
AC A0A0W8CQJ8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=AM587_10009885 {ECO:0000313|EMBL:KUF86414.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF86414.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF86414.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF86414.1}.
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DR EMBL; LNFO01002287; KUF86414.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8CQJ8; -.
DR EnsemblProtists; KUF86414; KUF86414; AM587_10009885.
DR OMA; QLAQWED; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 2.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUF86414.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1890..2557
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2663..2985
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3012..3044
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 3044 AA; 343234 MW; 0C66B4BE39BA9ED0 CRC64;
MATRSSAEEA EKSDVDNLLR IVRAHQRQHD DRTYDSTAPA AIRRCKTMLT KLRKLLPKLM
RPVATLAMDK AVPVLQDLCQ LLKLLLGGGA CPHSMTLFME SNTGVARGDN PASSGFPSYP
TMATMLFYMV SFYTNNNMRE AQRDVRDVTL QMVLFLQRND VYGFIHFFRD TVQLFEDCFL
LEESLKNRNS TNVLPGGASI ACYLDTAIHV YQDADGPLGA KSNVTLCGCM PITDVKQLYE
RREQLKQMLP SIHVSSYGMV VALRQSVIVL VDRIIREHNA MLEGDQSFDR LCQLVELSIS
KNXLLVKTSD GMSVNGAVSS QGADEVTRST LRLLHTILQV SVSKERRFVR LTLMYFKASF
LRGANPWTWK ACAAILELIG ASYSRISKFA SDALWPPFES WVYGNMDLVR GASHESKHSV
ETIWAAVLSI LGVYTRQSNT ASSASLFVDL LEFVDLKMLN PAMISGVIDG IHHVLSTKEM
LTKMVRFISN ELASNDPSTT SSSQTSANAS RKRKRNKLFV ERQTLLPGLR RENSTELHEK
LGRWLLDLIS FGGGSDRKSI LGISTGLRVI LPLRRYIAAF ARLESFAIFR ALLQRVDLVV
NTYAPSLTSL TSEYLDLWIV LLRYFDDHEL EKYRGLLTKV VESVETQRIF EHSVERDNSF
IVPDCWEFVD FLQVYQRRPQ CHDMSPSERL GEVSYEHLRS ADAVLDVLFR KSVALRGPFL
VYFVWSRPVT LNIVDEDSWR NALPWKIVYR TILQETSLDV AVCSYLAMAP LLAFFVVAGS
LTTPKKMVTC IMEAFSNKMQ RTGSDTTSLA ITQACGAVLC AAAYGQTFAE GINYYSDRRE
NAAGCHIKSC QCRNIANGCQ TMPIPLSLFE PIICGETGSA TELVQVVKVN ALSSVFEHCE
VDYGNDQTAM QFVEHLLTCF EHRSKLVRQA VLESIVHQPR LLDAMIDPAK DGLAGLMERL
EGHLTAAEES NDDSEIAEMM LASGSIGCEC DPHQGDRGDN CTWILLRLVS LWNRFMIANR
SRCAVLAYSQ ICRITTHHQI SWRRLCVDFP EILYYPLIDE LLETRNLKLF LHTFMGGKVD
TKVFLKASAP YVLPKYVVQQ NERMLHAFID EFNGTGEDIE MNSDGPIEDQ PMNITNLLLN
HLDYILRDLL IHQVQAVSNK NRLAEWEFLF KFLPENSTVR DVITHSSLRL MNLLAWELGG
PRSRMAKRAM REVANCLNED SRDAEAIEQV ASLQPGEGCM PRQFFLALMT DLGNRISGKN
SSAMKIRAIK SIDRLLDLYS GSSADPGSAQ NSGVVDPFVP KVMATLKVGL TEHALQEHAI
QAWGNFLQML STKALEANLS SIVVSLLPCL GHETSAILIE DGSITGSQCW NVESLEHFRQ
NGLGQVGSPG NRDEAQMKCM AAAVSILRYL FIEKGEELKP SFPKIPLLPS IPELDEIYVV
LYEEDGDPRC RSLREYLMNL SAYVNHLDVA VREMALTQLL RCLVVRGAEL ETLMQNEGDI
FIDRALASVV QSILQLSRTE SHVPIKLLCA RCLGALGAID GARVPLNMFY TSGPQGGAAV
AKEKQYQKIE YSTKDLAIVL IETWLVKELR AAPENTDSLA FAIQELLKFL AELTADPQHS
GQSLPTLNFG SSYKSRQDSS APMPDWMKRR FERKDVLQFV EPYWSTNYVV SGGRSSHRNG
SSGSDLRASA SVDHPARDDI SFYEVYGTSY EDWILNWCRR LISLSQPPER KIFLACRTAL
PTCPQISRFL LPYLIQNVLR SGRSEVGEEL KKEVMAVLED QDCGILVDDV LMASESEHTN
DSLISTGDAS EKGVGDFFRR HDQCSQTIFS TIDELNEWIW TSEKKRLALS ASAASRQMSA
SGRSDVASEI DDDHEKEYLE EFLKGIPSRS LSNAAYQIKA YARAIQYFEV HLRQEEFNET
EPRSADVEMA GPVRLSLVSK NAIYLQQLYK SVDEPDSLIG LASLRRLHDA YRHNDARTDT
PDEIQEEGLT LTDLMHQIVD HEQLAQWEDA LACYEQAIQE VQSALSSRSL PPSRPLYSQL
AMMQPPAQIL DVENAHKDPD TIKPELYGGM IGCLIQLGRL ESALQHINGI VTQEPQFMAT
MYPYALECSW RLSRWELLTD LLSAEKQNPL LLSSGSSAND TTSTRLKGFD VSQLMLVRVL
HSLHGGQQEE FQGHLKAARL ELMGPLAAAS AESYQRAYPL LHDLHFLHEA EQGFIFLQNA
KESDDLSRRS LLWKKQSPWK MRYDAMATQL KYRDPILALR RVILHEAGLL NEVSENWLLY
AKLTRKEGFI RTATSAVMHA QAMDNQYATI EKAKLLALQI LEPVDIDAST LDFDVEDPHL
CAKNLLLATN WMQKSGQRQG KKVIERYQAV IRFDPKWEKG YFFLAKYYEY LLNMSHPDAL
NGSMSSDEAA DLLVDSVFHG HLINLMKNYV LALAHGTKFV FQSLPRLLTL WFDLGEVLYG
SSSGRSSNKA NKAMRQIEIG LSQSTNEHKV LTDITQVVGE AIASLPAYEW LVCFPQVTSR
ICHPNPEVVD SVKKIMVQVL VAYPTQAMWS LLGLSRSLNS QRKNRAREII SSAQQQFLLQ
GLKEIADSFS EGMKMAEELI SLAAHDPGNS KRKIHIRLSR IRTKILVPIQ AALTTILPTS
GLAPRDEHHV AFSSNAQVYI KAFSDKADVM MTKEKPKRIE VLGTDGLLYP FLCKREKNGD
LRKDARMMEF NSMINRLLQK DREGRKRKLR LRTYAVVCLN EESGLMEWVR HTRAMRQLIG
QIHKTERGYI QPVRLTHEIK EQYLSMQKKY ANNPTAMARF YCREILSMPV FTPRFHQWFY
NNFADPTAWF EARLMFSRSA AVWSMVGHIV GLGDRHGENI LIDCTNGECV HVDFDCLFDK
GLKLTKPEIV PFRLTPNIID AFGITGYEGV FRRVSEVAMQ LLRENKATLR SVLESFIHDP
LVEWGRRGKA TQSSANSGKT AAELSSERSK QETRLVLRTI DDRLRGVYNL GDAIRPLVST
SHRNILPENE TLPLSVQGQV DKLIHEATSN ENLAQMYIGW MPFL
//
