ID A0A0W8CRX4_PHYNI Unreviewed; 640 AA.
AC A0A0W8CRX4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 13-SEP-2023, entry version 30.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=AM587_10004178 {ECO:0000313|EMBL:KUF65638.1}, AM588_10001224
GN {ECO:0000313|EMBL:KUF86668.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF86668.1, ECO:0000313|Proteomes:UP000054636};
RN [1] {ECO:0000313|Proteomes:UP000052943, ECO:0000313|Proteomes:UP000054636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943}, Race 0
RC {ECO:0000313|EMBL:KUF65638.1}, race 1
RC {ECO:0000313|Proteomes:UP000054636}, and Race 1
RC {ECO:0000313|EMBL:KUF86668.1};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF86668.1}.
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DR EMBL; LNFO01006097; KUF65638.1; -; Genomic_DNA.
DR EMBL; LNFP01001342; KUF86668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8CRX4; -.
DR STRING; 4790.A0A0W8CRX4; -.
DR EnsemblProtists; KUF65638; KUF65638; AM587_10004178.
DR EnsemblProtists; KUF86668; KUF86668; AM588_10001224.
DR OMA; CSAMTHH; -.
DR OrthoDB; 2140072at2759; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR Proteomes; UP000054636; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 1.20.120.1910; Cysteine-tRNA ligase, C-terminal anti-codon recognition domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00041; Cys_tRNA_synth; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KUF65638.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 20..332
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
SQ SEQUENCE 640 AA; 73472 MW; 31AB2964868A9DF8 CRC64;
MFNALTGQCE PFPRETSATP NVLKWYACGP TVYDRAHLGH ARAYVSQDIL RRVAERTGGY
NVQLVMGVTD VDDKIIKRAK EKNVSFETLA REQEQQFFAD MTKLYVKPPT AITRVSEHLP
EIIKYIKEIQ NKGFAYEAVD GSGVYFNTQQ LGDKYGKLDP RRQTQQDEQL LAAVEQSDVV
EEEEKVKKDP RDFALWKAAK EPDEPAWPSP WGMGRPGWHI ECSAMTHHVL GDKLDVHTGG
VDLRFPHHNN EIAQCEAHNH QQCNHDEEWC KHFVHFGHLY IRGRKMSKSL KNFISVRDFL
QDGHTADHFR LFCLQFKYRA NLVYSEDRVR DAEAVADRLR GFFRSVTAYG DHEISSSGHT
QHIKSKRCEQ LDLELLDALF ATRAQVDAAL LDDLDTPRAL SLVLELVSRG NTYLLASRGD
TEAPDEVLMS LTDYVLDVLD LFGLEGLHAE FSTMMRRRFT SRHSETQHKV EESDELVSRD
DHEALLRSLL KFRASVREEA LRDPKQPGNA RVLSLCDDLR NKELPQLGIQ IEDLSPGRSV
FKLLSRTERK AETEDTKTTA THTLKQKQQE FDALMQISPS EFFKNAPEFT GRFNTFDADG
FPTHEHGEPL TKSQRKKLAK KLAKHEKSYA KYWQTRKEVQ
//
