ID   A0A0W8DSS8_PHYNI        Unreviewed;      1505 AA.
AC   A0A0W8DSS8;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Anoctamin-10 {ECO:0000313|EMBL:KUF79583.1};
DE   SubName: Full=Pyruvate dehydrogenase E1 component subunit alpha {ECO:0000313|EMBL:KUF99421.1};
GN   ORFNames=AM587_10016813 {ECO:0000313|EMBL:KUF79583.1}, AM588_10010725
GN   {ECO:0000313|EMBL:KUF99421.1};
OS   Phytophthora nicotianae (Buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF99421.1, ECO:0000313|Proteomes:UP000054636};
RN   [1] {ECO:0000313|Proteomes:UP000052943, ECO:0000313|Proteomes:UP000054636}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Race 0 {ECO:0000313|EMBL:KUF79583.1}, race 0
RC   {ECO:0000313|Proteomes:UP000052943}, race 1
RC   {ECO:0000313|Proteomes:UP000054636}, and Race 1
RC   {ECO:0000313|EMBL:KUF99421.1};
RA   Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT   "Genomes and virulence difference between two physiological races of
RT   Phytophthora nicotianae.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUF99421.1}.
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DR   EMBL; LNFO01004777; KUF79583.1; -; Genomic_DNA.
DR   EMBL; LNFP01000027; KUF99421.1; -; Genomic_DNA.
DR   EnsemblProtists; KUF79583; KUF79583; AM587_10016813.
DR   EnsemblProtists; KUF99421; KUF99421; AM588_10010725.
DR   OMA; WENHRTV; -.
DR   OrthoDB; 53797at2759; -.
DR   Proteomes; UP000052943; Unassembled WGS sequence.
DR   Proteomes; UP000054636; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF73; INCREASED SODIUM TOLERANCE PROTEIN 2; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF04547; Anoctamin; 1.
DR   SMART; SM00248; ANK; 5.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Pyruvate {ECO:0000313|EMBL:KUF99421.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        735..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        769..789
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        844..865
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        885..906
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        927..950
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1064..1088
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          728..1200
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   1505 AA;  170805 MW;  4A73E7D1ABB30769 CRC64;
     MDLYEACENG NEERVVELLV FSKLSPASQL RARGIAGRTA LLAACMGGQA SVVRLLLGEK
     CVVHFTSRSE DEVVELLKPL VKLFQQFPSS SALFKVSMVT KDGGSDVVPM AEVQLPPLWA
     IPPSELLEGK QHVDYFGNTP LQCVSCFGCG SNAKHIDDGL DMTKQLLVHG DQPNLPKKSN
     KWAPLHWAAY NGNHEQIAML MNPVLHIGGG IQRFAKTQFA IPLMIDTDDL FAVDIAGRRG
     LALKDERTTL QRQVSSKDDE PNGEYVRWRL RLDHVEVVRL LIHEFLANGA HLTRYVAEMN
     ARNPLYPQKN KSNLLTVQDA VRYAQHLLYW AGCFGLVEDA RSLLQLELKM SSISSNSGAK
     AAVKPLVAQS TDDNNLKISL RMLYTCSCEY GKRQSVLHAV AAHGQLEILK LFLDKMLDDQ
     LHPSDSATLI GISKLNGVKP KKNIVVPIVM TMEMTESNNE TERTEQLNIL DYVNAGWTNY
     RNETPLFHAI LYLQDSAVRL FANILCPKSL AWELENVNVE GSLLHHISSE TSRQTLGIEH
     QSARPEYVML FDGMRKKQFK ETVIETMHEE SSIAPSLVVT RSGVRETVSG TCKARGEIDY
     LVVGAADEVL IQQAQVLQLK VKHRGSSTRS IYNASSPESF ESFRSLQRQQ VILSIIQRKI
     NLQKHIKNGN IITIFPLHDV MGCRNIIRHW GYTDSSQRIF QPFTGNSLEQ FFLERKRHQY
     EMLWPLLTYF GEKHAFYYAF VTFYTVWLLP IAVLGMACQM LWLANNVSFV PPLFAIVVSI
     WATLMVECWK RKRSEIQRKF GHFRRNRSEE TPGFYGDFLV ETTMIRAKCA VDVSFPRAVQ
     LVRIYTGIPL LMTMAIAAVV IFVAVKTNTA SSAVVHNAMP WLPVIFVPYV VPFMNAVSML
     LLDTWYTRLA RSLTTWENHR TVWEFESMLA TKLFSFKFLN AFISLFWIAF VDQNATALRK
     QLLIIMGVRQ LWNSIQRDVL PMFHVRYRWK NAGFRFRQAS GRVKNCWSMS SHEWYDAELS
     YSSTAMSLSG KERILPPPPM VLLQELMYPH DFLMGKQMEV VLQFGYVTMF VSVLPVAPLF
     ALLSNVVATR LDVLSCTQAK RRPPFESETE VSTFMSILEF MSFAAVAVNC AVLFFTTRSD
     FESLIQVIRP GWREDTTTDN SSAYVTELWL LLVIEHVVLG AKALLSLVID DSASWVRLDE
     DQTDEEEKKR MLVVNTPIYP ATVRSSTEDL DMTQHRGGVD QSKFNQVLAK QYLVALQERD
     EALKREQTAR QLLAESMKYA EKAQIQTVVA SSSNESAATN LTPCDSNSGR VPTTIEDERN
     LDAFNARDSR SSELGRRHCF LCFALRNLRI PAEKRCLSCH IALCFACDEI IHLDDLGVKE
     LPHFRVKMCE EMSRKTVIAD EHSVRIKVES NNIDVSPDYH STRRCSGHEK KQLRELRRHV
     ESFISHCDVS NAQQLTSDEA FKRCCANVRI ALRYLRNHER QRLYLESSNP AVSPALASVS
     KELCD
//