ID A0A0W8DYH2_PHYNI Unreviewed; 2046 AA.
AC A0A0W8DYH2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Xaa-Pro aminopeptidase P {ECO:0000313|EMBL:KUG01431.1};
GN ORFNames=AM587_10015550 {ECO:0000313|EMBL:KUG01431.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUG01431.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUG01431.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00169}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUG01431.1}.
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DR EMBL; LNFO01000329; KUG01431.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8DYH2; -.
DR EnsemblProtists; KUG01431; KUG01431; AM587_10015550.
DR OMA; CPATERS; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR CDD; cd01831; Endoglucanase_E_like; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR040794; CE2_N.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR037461; CtCE2-like_dom.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF17996; CE2_N; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:KUG01431.1};
KW Hydrolase {ECO:0000313|EMBL:KUG01431.1};
KW Protease {ECO:0000313|EMBL:KUG01431.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT DOMAIN 1..125
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REPEAT 400..433
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 543..615
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 667..734
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 139..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 468..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 945..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..773
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2046 AA; 227648 MW; 29F34B8E589D1D59 CRC64;
MLVDPDMLRR ENLADELEQR FEIFVAPSNE RAFALLGLFQ VNFILLRLDI GNDQTASTSP
ALAFLREMKR SCFRTPVAAL VDSSFNTDHE AQKLLARALQ QGGICGYFEQ GLAPDIMTQR
IAKLLRSLTV AQNELTRCRG TATQSTQDEK SPSRKPQADN QAANKTRATP PGSATGSKRL
PTTEVPNTRP SSVKFDRPGM LLELSLNQRK QCLRQRETLQ ANLASAPHSV LGVDIDVSST
SPGRPDTPLT TCISPSFGST GRTTQVKKKI PPLPSPKQVS QLIYARPQEL QTRIDRHLYE
RVHISGPPGP VPQDPLLNHC VVIDPRAQGR DLIVGKAYML YCEQRLDEAL LHCDRALRTP
NSTLEKLARL LRGALYDARG EHVRAETEFL ACLQLDPSMH EAHFNLSVAR LKLGKDALAL
EALTQALTLD PQNDKYLQNR GLMYRRMGQF VEAQDEYCKR EVASGTHTAS TGSTLTKRGT
NSSSVSRSVL PTRGLSKCDL EDGLFAHLFG KPTPDKLALA CPSTERSLEM LSAIVARLQT
LLFFQDFSHE MLFQVAQALD YDVVACGKSF VLGEAHSQNF YVLLGGRLSI RRRVGTTDFG
STVTTHHLGT GSVFGCAGFT ISAQASLIAD ECAEIGILWP GDYAATIRAV TSQMNQDIFA
FLQQLRGFRL LTTSELGHVV GISERKRFRK GDVLLEQNEQ PRHLIVLWKG SCSVFQDFDN
APLSRRKLRR SANFDGWNED DEDDSDSDSS DSEGPGGSRR DQDEDDKGPP PFHRLIAKPD
WPLGFQARTR ARKYRRGRRD GLMLSQTPPV VRSLSTAPPL TMSLPMRRLK DKLSSNDKNA
LVQKCVAPAV FGESRFLDPT HSSSKCSVVA ESLVEVLLFD HMRLQEMDLQ SEVISELFDA
APKYRSEKEV AQKQADVATW DEYRNLRILE LSKNRWPDAK AIRMHQEQME EEPPASSRGR
WLARRRTSRL DSGGSRDDNS PPLTALASLL LSSHPPASMT ETRVLAISRG TSVGDDDEPT
DTSPNVYKFD VAQYKDGSFR FVPACARDLI KYTGRLLHHG AQSARKTKIN TVQFDWPAVA
FQISVRGTSS VAIRLKGDGN YFNVFVNNEL RCILRASLNA TCCDVAADLD AETEYTIRIC
KRTEPQMRGA MSTFKVCTFY GFIVEEKAEV LPVDQPEPQP VRKMEFIGDS DTCGFGNEGK
ASSAKNLFGM KGRMENVYNG YACITARMFD AEEHVLAWSG KGVHSNSADW GPNMPALWKS
TLASRPGDWD MASWIPDVVV INLGINDLSP PASAETDIIT GYATFLLEVR SYRPDAHIFC
VVYDDGCMSS EDSETNRKFV SLQLQEIIKV AISKVSKHDN KMHYAFIKVE EGLEKEDYAS
MMHYAVSGHV KIAKVLAEEI ALRTGIVFEV NWIMLPAEKL RELRVLMSRT NVRLLPLRHL
LGKTEKGAAS ELTGRPLQAF LVDTADAHQS EYVGDAHKRR EFLTGFTGSN GTALVTPDQA
FMWTDGRYFL QAEQELSDDW TLMKSEEPGV PSIEQWTKKN LPNDSCLAID PYLTSVLAAR
NFAKVLKETK IELVALHETE NLVDLVWEDR PAVAPSQVTF LSDEYTGRSV ADKLKSLREA
VKDKGADAIV LTALDDIAWL FNIRGNDVEF NPVVTSYAVV TPDKATLFLD AANQDDVTQH
LRPSGVECKP YSSMLKEVSA LTASNKDTKI LVDPAQCNVA VFLAIPAANR KEDTSVVMAQ
KAIKSAVEIE GMRQAHLRDG AALVKYFSWL EKEMDAGNED QWDEVLVADK QEQFRSQAKD
YVSLSFDTIS SIGANGSIIH YSPKRGECSK MSTSAMYLND SGAQYLDGTT DVTRTLHFGQ
PTAYEKSCFT HVLKGHIALA STVFPDKMEG VKLDAITRAP LWKAGLDYRH GTGHGVGAFL
NVHEKGVLMS FRLNPNGLKI QDGMVLSNEP GYYEDGKFGI RIESVMVVKK AHHIKSPLNR
DFCEFETLTM APIQQKLIDA SFLTPEEIKW LNAYHKKVHD KLQPLLKDDP DTYAYLVRET
KPLSLP
//
