ID A0A0W8IFZ2_9MICC Unreviewed; 821 AA.
AC A0A0W8IFZ2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727};
DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727};
DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943};
GN ORFNames=AVL63_02240 {ECO:0000313|EMBL:KUG58871.1};
OS Nesterenkonia jeotgali.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Nesterenkonia.
OX NCBI_TaxID=317018 {ECO:0000313|EMBL:KUG58871.1, ECO:0000313|Proteomes:UP000054023};
RN [1] {ECO:0000313|Proteomes:UP000054023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD08_7 {ECO:0000313|Proteomes:UP000054023};
RA Nair G.R., Kaur G., Mayilraj S.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUG58871.1}.
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DR EMBL; LQBM01000003; KUG58871.1; -; Genomic_DNA.
DR RefSeq; WP_058888553.1; NZ_LQBM01000003.1.
DR AlphaFoldDB; A0A0W8IFZ2; -.
DR STRING; 317018.AVL63_02240; -.
DR OrthoDB; 9802472at2; -.
DR Proteomes; UP000054023; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1.
DR CDD; cd04863; MtLigD_Pol_like; 1.
DR CDD; cd07971; OBF_DNA_ligase_LigD; 1.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR InterPro; IPR014146; LigD_ligase_dom.
DR InterPro; IPR014144; LigD_PE_domain.
DR InterPro; IPR014145; LigD_pol_dom.
DR InterPro; IPR033649; MtLigD_Pol-like.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR NCBIfam; TIGR02777; LigD_PE_dom; 1.
DR NCBIfam; TIGR02778; ligD_pol; 1.
DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1.
DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1.
DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1.
DR Pfam; PF04679; DNA_ligase_A_C; 1.
DR Pfam; PF01068; DNA_ligase_A_M; 1.
DR Pfam; PF13298; LigD_N; 1.
DR Pfam; PF21686; LigD_Prim-Pol; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KUG58871.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000054023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 613..737
FT /note="ATP-dependent DNA ligase family profile"
FT /evidence="ECO:0000259|PROSITE:PS50160"
FT REGION 472..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 90287 MW; 80DE19046A2C55B4 CRC64;
MASKRQQTVT VGGHKLRLSN LDKVLFPASG TTKGEVVHYL QTVADAMLPH TRNRPATRKR
WPDGVGTVDK PHEPFFRKNL EDSAPAWVPR QELEHSDHSN TYPLANEPAV LAWFGQVGAL
EIHVPQWRFN RKGEPQNPDR LVLDLDPGPG ADLADCAQVA RWCREILDEM NLPSVPVTSG
SKGIHLYAAL NGSYTSEQVS PVAHELAKAL EADHPDAVVS DMKKSLRQGK VLIDWSQNNR
NKTTIAPYSL RGRPGSSEGP YVAAPRTWEE LEDPDLAQLD MHQVMDRIAE GTDPLADFTA
DDDAADALPE TQDALSTYRS MRDAANTPEP VPSDSPASRS EDPIFVIQEH HATALHYDTR
LERNGVLVSW AVPKGPLLEV GQQRLAVMTE DHPIEYAEFE GTIPKNEYGG GEVTIWDTGT
VEIEKWEQAE GSGKVVFVLH GAPEGGLGGV PRRYALVQTD EAGKNWLIRM TKDQPKAQKS
SQTSSTPAKK STKSSEKNGK TTKKSAFPDP LPSPMLASPG KPSDIRGKGW ILEGKWDGYR
AIAAVHADGR VEIRSRNGKD FTQTFPELSE IANIIPAGTV VDGEIVALNS GSRPDFGLLQ
RRGKLTKAKE IEQTAKKIPV HLMLFDVLHT AEHGDLTDEP YARRRKILEE LAESGKHVQV
PGDLGDSLDE AMDVSLELKI EGLVAKRAGS PYRAGRRSED WVKLKHESHA DVVIIGWRQG
KGGRAKTFGS LLLGMTDDDG DLHYAGRVGT GFSDVELTDL RAELEKLVRK TSPVDDVPAE
DSADATWVTP KVTAEVRHSG VTRENRLRHP TWRGIRTSNE P
//