ID A0A0W8IG21_9MICC Unreviewed; 1231 AA.
AC A0A0W8IG21;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=AVL63_01265 {ECO:0000313|EMBL:KUG58720.1};
OS Nesterenkonia jeotgali.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Nesterenkonia.
OX NCBI_TaxID=317018 {ECO:0000313|EMBL:KUG58720.1, ECO:0000313|Proteomes:UP000054023};
RN [1] {ECO:0000313|Proteomes:UP000054023}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD08_7 {ECO:0000313|Proteomes:UP000054023};
RA Nair G.R., Kaur G., Mayilraj S.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUG58720.1}.
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DR EMBL; LQBM01000003; KUG58720.1; -; Genomic_DNA.
DR RefSeq; WP_058888400.1; NZ_LQBM01000003.1.
DR AlphaFoldDB; A0A0W8IG21; -.
DR STRING; 317018.AVL63_01265; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000054023; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000054023}.
FT DOMAIN 28..385
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 386..743
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 566..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 49..56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1231 AA; 135904 MW; C89404ED465790D7 CRC64;
MTALQTMRYS ARDIADALQR DTPAEDRKYP TAEQQAVIES GLDPMLVVAG AGSGKTATMA
DRVVWLVANG IVRPDQILGV TFTKKAAGEL RERITRKLEQ LLEAELISPA DVVPVEVSDT
VEHADISELL APAVSTYHSY ANTLVTEYGL QIGLEPETQL IGEAKAWQLV HRLVSAYDRA
EVLVEAEQSA GNLAGYVMRL AGDCAEHLQS PEAVEAHLDV ELARVDAWEQ AGAELKGKQI
DLVRALRVRR EMAELVRRYQ EKKLTDGLMD YGDLLRFAAQ IAQDVPSAGE AEREKYKVVL
LDEFQDTSYA QLALFSSLYG AGGSGGGMGH AVTAVGDPNQ SIYGFRGASA GQLFDFPQSF
PAVDPDTDQR RPASLLQLTK AWRNGERILD VANRLVAPFA PDAADSLDKP WRAHNAHLRG
ELKPLSPPDG AHTGRVRYGW YTSDVEESQA ITEQLSAVLR PDAQHGPDSD APSCAVLART
RAQLETIAEQ LRLAGLDYEL VGLSGLLSTP EVAEVLAYLR VIADPGRSDA LIRILAGARY
RIGPRDLLQL QRSARDLEGL RLRAPITEPH EGSAQSGETE TAAGVGGPAD AEDRYESTEL
EMDERASLVE ALERLKDSPD NAEQLGLSAE GHRRLVLAKE QIRRLRQWAT LDLGVLIQRI
VSDTGLDIEV AARPWEEQHH AARQLDALID QAESYAATET TPDLRSFLDW LDAAEEKERG
LEQADVEPTP GAIQLMTIHA SKGLEWDVVA VAGLREDKFP SAKADRWTGS NGMLPARLRG
DRRSIPQWDS EQPDLRSWAV SAGIGSWKQF TEDNRVFTQD VKDFSREEER RLAYVAVTRA
KKLLLCTGAC FYGTSAGKDP SEFLEEIRAV ADGFGDAAAA LEWAEVPDMK ANPVGNDLFG
AQWPYDPLAP LPIGRYRRQV HEGERTTLPQ INTVEAPKVQ PGRRAALTRA AALVEHAIAD
RTQSAATSSE AGSEASPLTP WEQEAEWVVD RAREQQRGTG KPHFPAHISV SSVVGMARDA
ESMAEFARRP VPVKPSQAAR RGTVMHEWIE EFYETRSRLP GIEEPYRGDE DLDDAFELST
VKERFIQTEW AQRRLYAAEI PVETTLDGVV IRGRIDAIFG KDDAGQDLTA EDFERWELKS
AQDRNAQMQQ CHWDLVDWKT GMVPTGKDLR EKQIQLAVYR LAFHRLYGVP LEQIGASFFY
VEHGVTVPGT DLPEEDALQE YIRGARGYFS G
//
