ID A0A0X1KQT7_9THEM Unreviewed; 328 AA.
AC A0A0X1KQT7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Glyoxylate reductase {ECO:0000313|EMBL:AJC73675.1};
GN ORFNames=AJ81_05015 {ECO:0000313|EMBL:AJC73675.1};
OS Pseudothermotoga hypogea DSM 11164 = NBRC 106472.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Pseudothermotoga.
OX NCBI_TaxID=1123384 {ECO:0000313|EMBL:AJC73675.1, ECO:0000313|Proteomes:UP000077469};
RN [1] {ECO:0000313|EMBL:AJC73675.1, ECO:0000313|Proteomes:UP000077469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11164 {ECO:0000313|EMBL:AJC73675.1,
RC ECO:0000313|Proteomes:UP000077469};
RA Zhang X., Alvare G., Fristensky B., Chen L., Suen T., Chen Q., Ma K.;
RT "Genome sequencing of Thermotog hypogea.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854,
CC ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP007141; AJC73675.1; -; Genomic_DNA.
DR RefSeq; WP_031504950.1; NZ_JONI01000007.1.
DR AlphaFoldDB; A0A0X1KQT7; -.
DR STRING; 1123384.AJ81_05015; -.
DR PaxDb; 1123384-AJ81_05015; -.
DR KEGG; phy:AJ81_05015; -.
DR PATRIC; fig|1123384.7.peg.990; -.
DR OrthoDB; 9786364at2; -.
DR Proteomes; UP000077469; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000077469}.
FT DOMAIN 6..321
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..289
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 328 AA; 36551 MW; E6A90817697EC46A CRC64;
MNRFKVFVTR KILEEGLNML KERYDVEVSD YDGVIPREML LEKVKGVDAL VSLLTDNIDA
EVMDAAGPNL KIIANYAVGY NNIDVEEATK RGIMVTNTPG VLTETTADFA WTLLMAIARR
VVEADRFVRE GKFRGWEPML LIGTDVHGAT LGIVGFGRIG QAMARRALGF NMRVLYYDNA
RVDEQIEKEL KATFVDLPTL LKESDFVTLH VPLTKETHHL IGEKELKMMK KDAYLINTAR
GPVVDEKALV KALKEGWIKG AALDVFENEP EVEPELLKLD NVVLAPHIAS ASYATRSKMS
VMVAENVIKA LSGEVPPNLV NPEVLKKK
//
