ID A0A0X1KS63_9THEM Unreviewed; 469 AA.
AC A0A0X1KS63;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Alpha-glucosidase {ECO:0000313|EMBL:AJC74024.1};
GN ORFNames=AJ81_07280 {ECO:0000313|EMBL:AJC74024.1};
OS Pseudothermotoga hypogea DSM 11164 = NBRC 106472.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales; Thermotogaceae;
OC Pseudothermotoga.
OX NCBI_TaxID=1123384 {ECO:0000313|EMBL:AJC74024.1, ECO:0000313|Proteomes:UP000077469};
RN [1] {ECO:0000313|EMBL:AJC74024.1, ECO:0000313|Proteomes:UP000077469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11164 {ECO:0000313|EMBL:AJC74024.1,
RC ECO:0000313|Proteomes:UP000077469};
RA Zhang X., Alvare G., Fristensky B., Chen L., Suen T., Chen Q., Ma K.;
RT "Genome sequencing of Thermotog hypogea.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|RuleBase:RU361152};
CC Note=Binds 1 NAD(+) per subunit. {ECO:0000256|RuleBase:RU361152};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 4 family.
CC {ECO:0000256|ARBA:ARBA00010141, ECO:0000256|RuleBase:RU361152}.
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DR EMBL; CP007141; AJC74024.1; -; Genomic_DNA.
DR RefSeq; WP_031504326.1; NZ_JONI01000006.1.
DR AlphaFoldDB; A0A0X1KS63; -.
DR STRING; 1123384.AJ81_07280; -.
DR PaxDb; 1123384-AJ81_07280; -.
DR KEGG; phy:AJ81_07280; -.
DR PATRIC; fig|1123384.7.peg.1463; -.
DR OrthoDB; 9808275at2; -.
DR Proteomes; UP000077469; Chromosome.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd05297; GH4_alpha_glucosidase_galactosidase; 1.
DR Gene3D; 3.90.1820.10; AglA-like glucosidase; 1.
DR InterPro; IPR001088; Glyco_hydro_4.
DR InterPro; IPR022616; Glyco_hydro_4_C.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF041089; alpha_gluc_AglA; 1.
DR PANTHER; PTHR32092; 6-PHOSPHO-BETA-GLUCOSIDASE-RELATED; 1.
DR PANTHER; PTHR32092:SF3; PUTATIVE-RELATED; 1.
DR Pfam; PF02056; Glyco_hydro_4; 1.
DR Pfam; PF11975; Glyco_hydro_4C; 1.
DR PRINTS; PR00732; GLHYDRLASE4.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|PIRSR:PIRSR601088-3};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361152};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361152};
KW Iron {ECO:0000256|PIRSR:PIRSR601088-3};
KW Manganese {ECO:0000256|PIRSR:PIRSR601088-3};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601088-3};
KW NAD {ECO:0000256|RuleBase:RU361152};
KW Nickel {ECO:0000256|PIRSR:PIRSR601088-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000077469}.
FT DOMAIN 205..441
FT /note="Glycosyl hydrolase family 4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11975"
FT BINDING 160
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR601088-2"
FT BINDING 181
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR601088-3"
FT BINDING 210
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR601088-3"
SQ SEQUENCE 469 AA; 54819 MW; 70316ED7A5251162 CRC64;
MKITIIGAGS VRFAQQIIGD IAQTEELSKS DTHICLMDIN EERLNASYVL AKKYVHELGS
PVKIVKTAQM DEAIEGADFV INTAFPYDPR HHEDGFRRWD AVTEIAEKHG YYRGIDSQKL
SMVSTYTYVL SSYPDIKLAI DIAKKMERLA PSAYLMQTAN PVFEITQAVR RTTKVNIVGF
CHGVAGVYEV FERLKLEPEK VDWQVAGVNH GIWLNRFRYE GKDAYPLLDE WIEKELPHWK
AKSPWDIQMS PCAMDMYRFY GMLPIGDTVR NGTWKYHYNL ETKRRWFGEF GGIDNEVERP
KLHELLRNAR KRLIELARQV ELDPSVKLTE AFAEIFRKGR MSGEQHVPFI NAISNNKKVR
LFLNVENQGT LKDFPDDLVM ELPVWVDKEG IHREKVEPDL TERIKKFYLW PRILRMEWNL
EAFFSRDRKV LEEILIRDPR TRSYEQVVAV IDEILSLPFN EELRKHYSV
//
