ID A0A0X3APD2_9FLAO Unreviewed; 704 AA.
AC A0A0X3APD2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN ORFNames=Ga0061079_105171 {ECO:0000313|EMBL:CVK16212.1};
OS Apibacter mensalis.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales; Weeksellaceae;
OC Apibacter.
OX NCBI_TaxID=1586267 {ECO:0000313|EMBL:CVK16212.1, ECO:0000313|Proteomes:UP000182761};
RN [1] {ECO:0000313|EMBL:CVK16212.1, ECO:0000313|Proteomes:UP000182761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R-53146 {ECO:0000313|EMBL:CVK16212.1,
RC ECO:0000313|Proteomes:UP000182761};
RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA SanMiguel P., Csonka L.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC -!- SIMILARITY: Belongs to the peptidase S9A family.
CC {ECO:0000256|ARBA:ARBA00005228}.
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DR EMBL; FCOR01000005; CVK16212.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0X3APD2; -.
DR STRING; 1586267.GCA_001418685_01058; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000182761; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000182761}.
FT DOMAIN 26..427
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 485..699
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 704 AA; 79226 MW; 874D8A86B8DDA94D CRC64;
MIKPKIITLS LITILTVNAQ HMKYPTTEKG AEKDDYFGEK VTAPYRWLED DQSPKTKKWV
NNQNKLTFEY LYKIQYRNQI KDQLKELWNY ERISAPFEEG EYTYYYKNNG LQPQSVLYRR
LTAGGKEEIF LDPNAFSTDG TTSLGGISFS KDGSLAAYQI SEGGSDWRKV IIIDTNTKKQ
VGDTLKNVKF STVAWKSNEG FYYSGYQKPK IGSPLSGKTE HHILFFHNLH ESQSKDQIVF
GGEKTPRRYI NASVSEDQRY LIITAANSTS GNELYIQDLK TPNKILPVVT GFTNSYEVVT
TDGDWIYLQT NRDAPNQKLV KINASQIKTQ SPKWETVIPE TKSVLKVSSA NTYLFAEYIV
DVHTEVKQYD LNGKLLRTID LPGLGQAAGF SGKNNQKEIY YSFTNYIYPS TLFKYNTENG
VSELYQKPVI NFNPEEFESK QIFYTSQDGT QIPMTLTYKK GIKLNGKNPT LLYGYGGFEI
SLLPAFSVPT AVWLQNGGVY AVANIRGGGE YGRKWHDAGT RLNKKNVFED FISAGEYLIA
NKYTSSSYLA LSGGSNGGLL VGAVMTMRPD LAQVALPAVG VLDMLRYHTF TAGAGWAYDY
GTADDNKEMF TYLKSYSPVH NVKKGVCYPA TLITTGDHDD RVVPSHSYKF AAELQEKQSC
NNPVLIRIET RAGHGAGKPI DLLIEEIADK FAFTFNNFGI KELK
//
