ID A0A0X3BL68_9EURY Unreviewed; 303 AA.
AC A0A0X3BL68;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=polynucleotide 5'-hydroxyl-kinase {ECO:0000256|ARBA:ARBA00012157};
DE EC=2.7.1.78 {ECO:0000256|ARBA:ARBA00012157};
GN ORFNames=MMAB1_1664 {ECO:0000313|EMBL:CVK32877.1};
OS Methanoculleus bourgensis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=83986 {ECO:0000313|EMBL:CVK32877.1, ECO:0000313|Proteomes:UP000069850};
RN [1] {ECO:0000313|EMBL:CVK32877.1, ECO:0000313|Proteomes:UP000069850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Methanoculleus sp MAB1 {ECO:0000313|EMBL:CVK32877.1};
RA Manzoor S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl
CC groups of both single-stranded RNA (ssRNA) and single-stranded DNA
CC (ssDNA). Exhibits a strong preference for ssRNA.
CC {ECO:0000256|ARBA:ARBA00024737}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end
CC 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+);
CC Xref=Rhea:RHEA:15669, Rhea:RHEA-COMP:13180, Rhea:RHEA-COMP:13184,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:136412,
CC ChEBI:CHEBI:136416, ChEBI:CHEBI:456216; EC=2.7.1.78;
CC Evidence={ECO:0000256|ARBA:ARBA00024622};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-
CC monophospho-ribonucleoside-RNA + ADP + H(+); Xref=Rhea:RHEA:54580,
CC Rhea:RHEA-COMP:13935, Rhea:RHEA-COMP:13936, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:138282, ChEBI:CHEBI:138284,
CC ChEBI:CHEBI:456216; EC=2.7.1.78;
CC Evidence={ECO:0000256|ARBA:ARBA00024635};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
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DR EMBL; LT158599; CVK32877.1; -; Genomic_DNA.
DR RefSeq; WP_062263484.1; NZ_LT158599.1.
DR AlphaFoldDB; A0A0X3BL68; -.
DR GeneID; 27137479; -.
DR KEGG; mema:MMAB1_1664; -.
DR OrthoDB; 107367at2157; -.
DR Proteomes; UP000069850; Chromosome chrI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051734; F:ATP-dependent polynucleotide 5'-hydroxyl-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF3; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000069850};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 28..203
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
SQ SEQUENCE 303 AA; 32885 MW; 5C3875439F84F6F1 CRC64;
MIIIGEGWEE LAAALSQADT PERIYVIGST NSGKTTLCRY LVDKTAAHMR AAYVDCDTGQ
STVGPPTTEG MVLYPLPPGL PGRPHLRFVG STSPGGHFLQ TLTGAKRLVE KAAELGADAT
IIDSPGLVFG GVGIEFQVQM VDLLRPTRLV ALQHGRELEP LLANFARHPA ITIHRVPVSP
AAVTRTATER RRYREERFAA YFAEALPREV PIRGLGLQGR IPDLKNPHGA RRRLVSLNDH
DNFSLALGIA GEMHTRRRLL TVVAPPFDPA AVASIRFGSL NLDLDAEPGS MESHAGKSER
KRT
//