ID A0A0X3BMR7_9EURY Unreviewed; 359 AA.
AC A0A0X3BMR7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=NADH-ubiquinone oxidoreductase chain 49kDa {ECO:0000313|EMBL:CVK33189.1};
DE EC=1.6.5.11 {ECO:0000313|EMBL:CVK33189.1};
GN ORFNames=MMAB1_1976 {ECO:0000313|EMBL:CVK33189.1};
OS Methanoculleus bourgensis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=83986 {ECO:0000313|EMBL:CVK33189.1, ECO:0000313|Proteomes:UP000069850};
RN [1] {ECO:0000313|EMBL:CVK33189.1, ECO:0000313|Proteomes:UP000069850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Methanoculleus sp MAB1 {ECO:0000313|EMBL:CVK33189.1};
RA Manzoor S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
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DR EMBL; LT158599; CVK33189.1; -; Genomic_DNA.
DR RefSeq; WP_062263991.1; NZ_LT158599.1.
DR AlphaFoldDB; A0A0X3BMR7; -.
DR GeneID; 27137716; -.
DR KEGG; mema:MMAB1_1976; -.
DR OrthoDB; 43567at2157; -.
DR Proteomes; UP000069850; Chromosome chrI.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050136; F:NADH dehydrogenase (quinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR001501; Ni-dep_hyd_lsu.
DR InterPro; IPR018194; Ni-dep_hyd_lsu_Ni_BS.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR43485:SF1; FORMATE HYDROGENLYASE SUBUNIT 5-RELATED; 1.
DR PANTHER; PTHR43485; HYDROGENASE-4 COMPONENT G; 1.
DR Pfam; PF00346; Complex1_49kDa; 2.
DR Pfam; PF00374; NiFeSe_Hases; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR PROSITE; PS00507; NI_HGENASE_L_1; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|PIRSR:PIRSR601501-1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR601501-1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601501-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR601501-1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CVK33189.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000069850};
KW Ubiquinone {ECO:0000313|EMBL:CVK33189.1}.
FT DOMAIN 120..283
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
FT DOMAIN 287..359
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
FT BINDING 46
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 65
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 68
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 68
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 320
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 353
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 356
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
SQ SEQUENCE 359 AA; 40295 MW; 04DFAB812C718F1F CRC64;
MPERIVVPFG PQHPVLPEPI HLDLVLEDEL VVDVVPSIGY IHRGLEQLVQ KREYTEYVYV
AERICGICSF MHALCYCQGI EHIMEIEVPD RSRYLRTIWS ECSRLHSHLL WLGLFADGMG
FENLFMRSWQ LRESVLDVFE DTTGGRIIQG TCKVGGVRRD IGQEKLDEMH RALDPFEEKC
RDLGDVFLND ETVKYRLQGL GVLSKDEAYT LGAAGPTLRG SGVAVDHRET GYAAYGDLGF
KPVVETAGDC YARCAVRVRE LYSSIDLIRR AIEEMPEGPI DVKVKGAPNG EYFSRVEQPR
GEVVHYLRGD GTKHLARARI RTPTLANIPA LVKMLPGAQL ADVPVVVLSI DPCISCTER
//
