ID A0A0X3BP49_9EURY Unreviewed; 516 AA.
AC A0A0X3BP49;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:CVK33620.1};
GN ORFNames=MMAB1_2407 {ECO:0000313|EMBL:CVK33620.1};
OS Methanoculleus bourgensis.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=83986 {ECO:0000313|EMBL:CVK33620.1, ECO:0000313|Proteomes:UP000069850};
RN [1] {ECO:0000313|EMBL:CVK33620.1, ECO:0000313|Proteomes:UP000069850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Methanoculleus sp MAB1 {ECO:0000313|EMBL:CVK33620.1};
RA Manzoor S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LT158599; CVK33620.1; -; Genomic_DNA.
DR RefSeq; WP_062264717.1; NZ_LT158599.1.
DR AlphaFoldDB; A0A0X3BP49; -.
DR GeneID; 27138069; -.
DR KEGG; mema:MMAB1_2407; -.
DR OrthoDB; 121419at2157; -.
DR Proteomes; UP000069850; Chromosome chrI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000069850};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 9..87
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 191..226
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 273..451
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 516 AA; 58959 MW; 908F4125E759E442 CRC64;
MIDLQSLPAE PGCYLFSDDE GSIIYVGKAK NLKRRVSSYF SRHDLDPKTR ILVAAIATVD
FIVTDTEVEA FILENTLIKK HQPKYNIDLK DSKSYAYIHI TDEPYPRFHV ARGPDGNGRY
YGPFVSARER DDLLRLLKRT FGLRSCRRLP RRPCLRAHIG SCSAPCTREI GEDDYQELVG
RAEAVLKGDI AGLIRTLREE MAACAEQQDY ERALELRDQV AALEGLRERQ HVDRQKTYNE
DIVNYIASDG TVFLMLFNVY RGTLAGKHEY TFDATEGFLE EFLTRYYADH DPPEEVILPE
AVDDAVADYL SHLRGGKVRM VVPQRGEKKK LLDLVRKNVE IGFFGDRIKV EELKRCLHLP
ALPVVVECFD ISHLSGTAMV GSMVRFRWGR PDKRNYRRFK IRTVEGIDDF AAIAEVVRRR
YSRLQREGGD LPDLIIVDGG KGQLAAAGAV LRELGLRVPI VAIAEREEEV FVPGFTHPLP
LDRHEKASLF IQEIRDEAHR FAITYHRTLR RKTVTP
//
