ID A0A0X3S1V0_9ACTN Unreviewed; 334 AA.
AC A0A0X3S1V0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=2-oxoisovalerate dehydrogenase {ECO:0000313|EMBL:KUJ37863.1};
GN ORFNames=ADL25_26575 {ECO:0000313|EMBL:KUJ37863.1};
OS Streptomyces sp. NRRL F-5122.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ37863.1, ECO:0000313|Proteomes:UP000054048};
RN [1] {ECO:0000313|Proteomes:UP000054048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ37863.1}.
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DR EMBL; LMWH01000241; KUJ37863.1; -; Genomic_DNA.
DR RefSeq; WP_059130363.1; NZ_LMWH01000241.1.
DR AlphaFoldDB; A0A0X3S1V0; -.
DR OrthoDB; 3457658at2; -.
DR Proteomes; UP000054048; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT DOMAIN 9..184
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 334 AA; 36109 MW; 9BE3A39E2D1B1E06 CRC64;
MTTVALKPAT MAQALTRALR DAMAADPSVH VMGEDVGTLG GVFRVTDGLA KEFGEDRCTD
TPLAEAGILG TAVGMAMYGL RPVVEMQFDA FAYPAFEQLV SHVSRMRNRT RGAMPLPITI
RIPYGGGIGG VEHHSDSSEA YYMATPGLHV VTPATVADAY GLLRASIASD DPVVFFEPKR
LYWSKDSWNP EEPQKVEPIG RAVVRRAGRR ATLITYGPSV PVCLEAAEAA RAEGWDLEVV
DLRSLVPFDD ETVTASVRRT GRAVVVHEST GFGGPGGEIA ARVTERCFHY LEAPVLRVAG
FDIPYPPPML ERHHLPGVDR ILDAVGRLQW EAGS
//