ID A0A0X3S3U4_9ACTN Unreviewed; 679 AA.
AC A0A0X3S3U4;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Short-chain dehydrogenase {ECO:0000313|EMBL:KUJ38652.1};
GN ORFNames=ADL25_22950 {ECO:0000313|EMBL:KUJ38652.1};
OS Streptomyces sp. NRRL F-5122.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ38652.1, ECO:0000313|Proteomes:UP000054048};
RN [1] {ECO:0000313|Proteomes:UP000054048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ38652.1}.
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DR EMBL; LMWH01000229; KUJ38652.1; -; Genomic_DNA.
DR RefSeq; WP_059129686.1; NZ_LMWH01000229.1.
DR AlphaFoldDB; A0A0X3S3U4; -.
DR OrthoDB; 9774430at2; -.
DR Proteomes; UP000054048; Unassembled WGS sequence.
DR CDD; cd08943; R1PA_ADH_SDR_c; 1.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001303; Aldolase_II/adducin_N.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR InterPro; IPR013454; Bifunc_RhaD/ADH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR NCBIfam; TIGR02632; RhaD_aldol-ADH; 1.
DR PANTHER; PTHR43669; 5-KETO-D-GLUCONATE 5-REDUCTASE; 1.
DR PANTHER; PTHR43669:SF8; SHORT-CHAIN TYPE DEHYDROGENASE_REDUCTASE-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF00596; Aldolase_II; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM01007; Aldolase_II; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT DOMAIN 9..211
FT /note="Class II aldolase/adducin N-terminal"
FT /evidence="ECO:0000259|SMART:SM01007"
FT REGION 19..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 71878 MW; 99B78BED332CE9A7 CRC64;
MAPHPEAAAL LARSHRLGAD PRNTNYAGGN ASAKGTDRDP VTGGDVELMW VKGSGGDLGT
LTGAGLAVLR LDRLRALTEV YPGVEREDEM VAAFDYCLHG KGCAAPSIDT AMHGLVDAAH
VDHLHPDSGI ALACAADGEK LTAECFGDTV VWVPWRRPGF QLGLDIAAVK KANPQAVGCV
LGGHGITAWG DTSEECERNS LHIIRTAEAF LAEHGRSEPF GPVIEGYEAL PEAERRERAA
ALAPHIRAVA SQDRAQVGHF TDADVVLDFL ARSGHPRLAA LGTSCPDHFL RTKVRPLVLD
LPPTAPLEQV AVRLKELHAA YREEYAAYYA RHALPDSPAM RGADPAIVLV PGVGMFSFGK
DKQTARVAGE FYVNAINVMR GAESVSTYAP IEESEKFRIE YWPLEEAKLR RMPKPRPLAT
RVALVTGAGS GIGKAIAHRL AAEGACVVVA DIDADRAAAV AEELGGADRA VAVTVDVTSE
EQIGEAFKAA VLAYGGVDLV VNNAGISISK PLLETSAKDW DLQHDIMARG SFLVSREAAR
VMIAQELGGD IVYIASKNAV FAGPNNIAYS ATKADQAHQV RLLAAELGEH GIRVNGVNPD
GVVRGSGIFA GGWGAQRAAV YGVEEEELGE FYAQRTILKR EVLPEHVAAA VFALTGGDLT
HTTGLHVPVD AGVAAAFLR
//
